Unlike C. violaceum, which has the genes for the aerobic UFA biosynthetic pathway, thegenomeofL. hongkongensis does not co...Feng Y, Cronan JE (2009) Escherichia coli unsaturated fatty acid synthesis. Complex transcription of the fabA gene in vivo identification of the essential reaction ...
The bacterial type II fatty acid synthesis pathway is regarded as an attractive target because it is distinct from the type I fatty acid synthesis pathway of mammals. However, the well-studied enzymes involved in SFA synthesis are largely conserved in bacteria and thus inhibition of these enzymes...
L.: Unsaturated fatty acid Bio- synthesis in TETRAHYMENA. J. Biol. Chem., 251, 1976, 23, pp. 7588-7592.THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 251, no. 23, 10th December 1976, pages 7588-7592, US; M.J. KOROLY et al.: " Unsaturated fatty acid biosynthesis in tetrahymena ", ...
of the NF-KB pathway (Ren J and Chung SH.J Agric Food Chem.2007 55: 5073-80). In addition, the ω3 PUFAs have inhibiting action on the synthesis of arachidonic acid to the benefit of the synthesis of docosahexanoic and eicosapentanoic acids (Calder P C. Lipids: 2001: 36, 1007-24...
Dietary unsaturated fatty acids: interactions and possible needs in relation to eicosanoid synthesis This review summarizes information concerning the metabolism of unsaturated fatty acids, with emphasis on tissue arachidonic acid levels and eicosanoids, and ... J Kinsella - 《Journal of Nutritional Bioche...
Mead acid (20:3n-9), a polyunsaturated fatty acid (PUFA), which is synthesized from oleic acid (18:1n-9) especially when HUFAs are deficient, was almost undetectable in FADS2−/− liver, confirming the necessity of FADS2 in the synthesis of this PUFA (Fig. 2b)13,16,17. ...
The cloning also confirmed the long-postulated hypothesis that the same pathway is followed in n6 and n3 HUFA synthesis. Dietary n6 and n3 HUFA both induce fatty acid oxidation enzymes in peroxisomes when compared to their respective precursor polyunsaturated fatty acids. This suggests that ...
fatty acid metabolism, we evaluated various nodes of the fatty acid synthesis pathway. Using RNAi we have demonstrated that depletion of fatty-acid synthesis pathway enzymes SCD1, FASN, or ACC1 in HCT116 colon cancer cells results in cytotoxicity that is reversible by addition of exogenous fatty...
The present invention relates to fatty acid desaturases able to catalyze the conversion of oleic acid to linoleic acid, linoleic acid to gamma-linolenic acid, or of alpha-linolenic acid to stearidonic
(4c,7c,10c,13c, 16c,19c-22:5), although with low efficiency and in competition withn-3fatty acid synthesis. EPA (20:5) and DHA (22:6) acids aren-3 PUFAs of great interest due to their health benefits. For instance, evidence supports their beneficial role in the prevention of ...