To drive the genetic basis of this and other cancers, extensive collaborative efforts have been established to sequence the genomes of numerous cancer types, predominantly solid tumors. This undertaking has led
Tumours might seem to be discrete entities, but each one is a roiling collection of cells. Instead of looking at the tumour as a whole, individual analysis of its many different cells is providing insight into cancer progression and the mechanisms underl
Mental status changes, such as a new onset of depression. A few rare types of pancreatic cancer cause hormonal imbalances that produce their own symptoms, which might include: Episodes of weakness,sweating, rapid heartbeat, irritability, or skin flushing related tolow blood sugar Severe watery dia...
Current approaches to overcome resistance are focused on combining PARP inhibition with other inhibitors of the DNA damage response, immune-checkpoint inhibition or targeted therapies. Targeting the acquired vulnerabilities of PARP inhibitor-resistant tumours might selectively kill unresponsive cancer cells. Pr...
Current oncologic treatments have brought a strong reduction in mortality in cancer patients. However, the cancer therapy-related cardiovascular complications, in particular chemo-therapy and radiation therapy-induced cardiotoxicities are a major cause o
6 Types of Cancer Cancer can occur anywhere in the body. Broadly, cancers are classified as either solid (for example breast, lung, or prostate cancers) or liquid (blood cancers). Cancer is further classified according to the tissue in which it arises. ...
Related Reading: HPV and Cervical Cancer: What’s the Connection? In addition to cervical cancer, HPV is considered a contributing factor to several other types of cancer, such as: Oropharyngeal cancers, a type of head and neck cancer particularly those affecting the throat and tonsils. Anal ca...
Antibodies targeting PD-1 or PD-L1 have had impressive and durable effects in a small subset of patients with certain types of cancer. This has been instrumental in fuelling the current excitement surrounding IO therapies, but many patients are resistant, or only respond transiently, to these ...
Telomerase is associated with cellular aging, and its presence limits cellular lifespan. Telomerase by preventing telomere shortening can extend the number of cell divisions for cancer cells. In adult pancreatic cells, telomeres gradually shorten, while
Cancer-associated fibroblasts (CAFs) are a key component of the tumour microenvironment with diverse functions, including matrix deposition and remodelling, extensive reciprocal signalling interactions with cancer cells and crosstalk with infiltrating le