Understanding the specialized cells, the elements of the cardiac conduction system, and the cardiac action potential is key to understanding the development of arrhythmias.Two types of cardiomyocytes generate and conduct electrical impulses:Cells that generate the stimulus to trigger a heartbeat. Examples...
can affect ion channel proteins including several K+currents causing action potential propagation abnormality and cardiac arrhythmias.26OFR also inhibits calcium sensor proteins in the excitation-contraction coupling causing myocardial stunning.27Heart as a pumping organ would require large amount of energy ...
As sepsis progresses to severe forms, cardiac dysfunction becomes a major concern, often manifesting as ventricular dilation, a reduced ejection fraction, and a diminished contractile capacity, known as sepsis-induced cardiomyopathy (SIC). The absence of standardized diagnostic and treatment protocols for...
Non-steroidal anti-inflammatory drugs (NSAIDs) inhibit the formation of prostanoids by the enzyme cyclooxygenase (COX). Work in the past 15 years has shown that COX exists in two forms: COX1, which is largely associated with physiological functions, and COX2, which is largely associated with ...
and calcium-dependent arrhythmias, the team combined the advantages of an ultrafast random access multi-photon (RAMP) microscope with a double staining approach to optically record action potential and, simultaneously, the corresponding local Ca2+-transient in different positions across the cardiac cells...
3. According to E(t) function, the shape of all the variables during the cardiac cycle remains unaltered for the different grades of p. The simulated pressures in the right atrium and in the pulmonary artery exhibit a positive and negative shift with p increasing, respectively. Consistently, ...
45 Given the substantial limitations in function associated with PCC, it is likely that many people, especially those admitted to the ICU during their acute illness, required pulmonary, cardiac, and general rehabilitation support, which may not be fully represented in measures of health care use. ...
its own set of symptoms, including changes in gastrointestinal pH [42]. Many symptoms of non-alcoholic fatty liver disease can be linked to comorbidities, such as obesity, which is the likely source of the reduction in cardiac output and CYP2E1 activity and expression seen in non-alcoholic ...
Cases of cardiac complications related to ZIKV infection include myocarditis, pericarditis, Arrhythmias, and heart failure [96,97,98]. Additionally, incidence rates of ZIKV infection are observed to be higher in females than males, and it is more common in older individuals than in younger ones ...
Patients undergoing extracorporeal therapies are more sensitive to extremes in fluid balance because both fluid overload and dehydration can impair cardiac, renal, and pulmonary function. Initiation of ECMO can lead to hemodynamic fluctuations due to membrane biocompatibility, leading to AKI through mechani...