Cardiac dynamics: a simplified model for action potential prop- agation. Theor Biol Med Model. 2012;9:50. https://doi.org/10.1186/1742-4682-9-50.Pen˜aranda A, Cantalapiedra I, Bragard J, Echebarria B. Car- diac dynamics: A simplified model for action potential prop- agation. Theo ...
Map-based model of the cardiac action potential Recent experimental-data based models are complicated for analysis and simulation. The simplified map-based model of the cardiac cell is constructed. The... EA Pavlov,GV Osipov,CK Chan,... - 《Physics Letters A》...
Simplified Insulin Tolerance Test Rats aged 24 wk were fasted overnight (n = 6 per group) and injected intraperitoneally with regular insulin (1 IU/kg). Blood samples were taken from the tip of the tail before (0 min) and after (30, 60, and 120 min) the insulin injection and ...
multiscale electromechanical model of left ventricle simulation [36]. Although simulated responses using these models have been compared with a wide range of experimental measures, their applicability to study myocardial diseases are limited. For example, simplified contraction models cannot be used to ...
valuable tool for studying arrhythmia-associated ion channels including those involving in CCIs. Researchers have also employed selective pharmacological ion channel blockers on 3D CMTs to study action potential (AP) alterations, providing a robust platform for in vitro cardiotoxicity assessment [92]....
A simplified, Langendorff-Free Method for concomitant isolation of viable Cardiac myocytes and nonmyocytes from the Adult Mouse Heart. Circ Res. 2016;119(8):909–20. Article PubMed CAS Google Scholar Zhang Z, et al. An improved procedure for isolating adult mouse cardiomyocytes for epicardial ...
Cardiac muscleSimilar to skeletal muscle but extrinsic innervation is only at the specialized nodal pacemakers; the action potential is conducted from cell to cell via gap junctions (nexuses)Similar to skeletal muscle but contraction is initiated by automatic firing of pacemaker cells; contraction is ...
Regional differences in action potential duration (APD) restitution in the heart favour arrhythmias, but the mechanism is not well understood. We simulated a 150 × 150 mm 2D sheet of cardiac ventricular tissue using a simplified computational model. We
Action potential BCT: Bioartificial cardiac tissue BHK: Baby hamster kidney BSA: Bovine serum albumin CAR T-cells: Chimeric antigen receptor t-cells Cav1.2: Calcium channel, voltage-dependent, L type, alpha 1C subunit CDM3: Chemically defined medium, 3 components CHIR(99021): Selective...
First, cardiomyocytes within these simplified structures tended to collapse inward toward the center of the canals, causing the formation of large gaps in the tissues that were filled with other cell types (Figure S2). Second, without sufficient anchorage of the tissue containing them to the ...