今天学习下如何下载UKBiobank的数据并进行整理,把它变成TwoSampleMR能够使用的格式。 数据下载 打开ukbiobank的官网:https://www.nealelab.is/uk-biobank 打开后往下拉,找到results can be found here,点击它: 点击之后即可来到数据界面,首先是README这个sheet,这里会有一些介绍,每个文件包含哪些内容,每个文件的列名是...
We were intrigued and aimed to fill the gaps by applying advanced ML to predict the disease progression of AATD-LD using real-world data from the UK Biobank. In this work, we aimed to: (a) establish a predictive ML model of clinical outcomes to assess disease progression of AATD-LD bas...
Using magnetic resonance images from the UK Biobank dataset, we create six whole-body atlases representing a healthy population average. We furthermore unbias them, and this way obtain a realistic representation of the population. In addition to the anatomical atlases, we generate probabilistic ...
The biobanking market size is forecast to increase by USD 1.67 billion at a CAGR of 9.04% between 2023 and 2028. The market is experiencing significant growth due to several key trends. The increasing demand for personalized medicine is driving market expansion, as biobanks provide a vital resou...
explore-ukb-data.Rmd + + + + + + The UK Biobank is a resource that includes detailed health-related and genetic data on about 500,000 individuals and is available to the research community. ukbtools removes all the upfront data wrangling required to get a single dataset for statistical ...
The role of common genetic variation on four lifetime treatment-seeking behaviours (treatment-seeking, treatment-receipt, self-help, self-medication with alcohol/drugs) was examined in participants of the UK Biobank (sample size range: 48,106 - 75,322). Treatment-related behaviours were only ...
Using data from the UK Biobank, we aimed 1) to comprehensively investigate the associations of the TyG index and TG/HDL-C ratio with the risk of CVD, and 2) to quantify the contribution of prevalent diabetes, hypertension, and dyslipidemia as potential mediators in the effect of the TyG ind...
If multiple effect sizes were reported in a study, those estimated in the largest sample size were used (eg, the combined replication and discovery phase). Effect sizes were not considered for the polygenic score if they were estimated with UK Biobank data to avoid potential overestimation. ...
UK Biobank is a large-scale prospective study with deep phenotyping and genomic data. Its open-access policy allows researchers worldwide, from academia or industry, to perform health research in the public interest. Between 2006 and 2010, the study recr
Data within biobanks capture broad yet detailed indices of human variation, but biobank-wide insights can be difficult to extract due to complexity and scale. Here, using large-scale factor analysis, we distill hundreds of variables (diagnoses, assessmen