We confirmed Rev-erbαas a negative regulator of Dec2 in mice and in Hepa-1c1c7 cells. Based on promoter analysis and luciferase reporter assays, it was found that Dec2trans-repressedUgt1a9via direct binding to an E-box-like motif in the gene promoter. Additionally, regulation of Ugt1a9...
Sult1c1 and Sult6b1 mRNA transcripts were below the detection limit in all investigated tissue samples. 4. Discussion In the present study, tissue distribution of resveratrol and its three major metabolites (resveratrol-3- O-sulfate, resveratrol-3-O-4 -O-disulfate, and resveratrol-3-O-...