We also observed UGT1A1 as a dimer using atomic force microscopy (Figure 2b). We next determined whether UGT1A1 binds to the UGT1A1-p.Q331X Journal of Human Genetics Truncated UGT1A1 colocalizes with intact UGT1A1 M Suzuki et al 160 Figure 2 UGT1A1 binds to UGT1A1 or UGT1A1-p...
Drug-drug interaction potential of antitumor acridine agent C-1748: The substrate of UDP-glucuronosyltransferases 2B7, 2B17 and the inhibitor of 1A9 and 2B7 ArticleOpen access22 March 2018 Background Herbal medicines are gaining popularity for the treatment of chronic and complex diseases as it...
Lin GF, Guo WC, Chen JG, Qin YQ, Golka K, Xiang CQ, Ma QW, Lu DR, Shen JH (2005) An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine- exposed workers in China. Toxicol Sci 85(1): 502–506. Lin J, Wang J, ...
All UDP-glucuronosyltransferase (UGT) isoforms except UGT1A4, 1A9, and 2B7 showed the capability to glucuronidate vanillin, and UGT1A6 exerted the higher V-max/K-m values than other UGT isoforms for the glucuronidation of vanillin when assuming expression of isoforms is similar in ...
Lin GF, Guo WC, Chen JG, Qin YQ, Golka K, Xiang CQ, Ma QW, Lu DR, Shen JH (2005) An association of UDP-glucuronosyltransferase 2B7 C802T (His268Tyr) polymorphism with bladder cancer in benzidine- exposed workers in China. Toxicol Sci 85(1): 502–506. Lin J, Wang J, ...
insulin-like growth factor-1 (IGF1); growth hormone receptor; UGT2B15; Laron syndrome; p531. Introduction The growth hormone (GH)-insulin-like growth factor-1 (IGF1) endocrine system is a major regulator of basic metabolic and developmental processes throughout life [1,2,3]. Among other ...