Protein ubiquitylation is a recognized signal for protein degradation. However, it is increasingly realized that ubiquitin conjugation to proteins can be used for many other purposes. Furthermore, there are many ubiquitin-like proteins that control the a
Binding sites of ubiquitin-protein ligase. Binding of ubiquitin- protein conjugates and of ubiquitin-carrier protein. J. Biol. Chem. 264: 10378-10383, 1989.Reiss Y, Heller H, Hershko A 1989 Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-...
Sane S et al (2014) Ubiquitin-like (UBX)-domain-containing protein, UBXN2A, promotes cell death by interfering with the p53- Mortalin interactions in ... Sane,Abdullah,D A,... - 《Cell Death & Disease》 被引量: 15发表: 2014年 Triad3A, an E3 ubiquitin-protein ligase regulating Toll-...
Phosphorylation of tau at a single residue inhibits binding to the E3 ubiquitin ligase, CHIP Hyper-phosphorylated tau accumulates in Alzheimer’s disease; but the roles of these phosphorylation sites are unclear. Here the authors show that phosphorylation of a single site, pSer416, limits its tur...
Crystal Structure of the Complex between Prokaryotic Ubiquitin-like Protein and Its Ligase PafA Prokaryotic ubiquitin-like protein (Pup) is covalently attached to target proteins by the ligase PafA, tagging substrates for proteasomal degradation. The ... J Barandun,CL Delley,N Ban,... - 《...
Aside from ubiquitin, a number of other small ubiquitin-like proteins also have essential roles as post-translational regulators of DNA damage bypass [21]. These proteins include the SUMO (small ubiquitin-like modifier) protein family (SUMO-1, 2, and 3), NEDD8 (neuronal precursor cell-expresse...
ligase is the founding member of a family of elongin BC-based ubiquitin ligases that include Cul2-Rbx1 or Cul5-Rbx2 modules. In the VHL ubiquitin ligase, the VHL protein binds directly to elongin BC through a conserved elongin BC-binding site motif (BC-box) with consensus sequence [(A,P...
Ubiquitin ligases provide more target specificity through their selective binding to protein substrates. Several ubiquitin ligases have been linked to cancer. The classic examples are MDM2 and IAPs, among others. There has been interest in developing inhibitors against MDM2 that regulate the expression ...
We identified a ubiquitin-like protein (UBL) as a protein that binds to KS-13. Real time PCR analysis of CD45+/Sca-1+/c-Kit+ HSCs derived from embryonic day (E)14.5 FL cells showed high expression of UBL compared to other fractions suggesting a possible role of UBL in HSC regulation...
人E3泛素蛋白连接酶AMFR (E3 ubiquitin-protein ligase AMFR)CLIA试剂盒 价格电议 起批量≥1 盒 最小起订1盒 供货总量46盒 发货地址上海市闵行区 建议售价￥电询/盒 更新日期2024年12月25日 产品规格96T 即时洽谈立即询价查看联系方式 收藏产品发送留言 ...