U2AF1 mutation connects DNA damage to the alternative splicing of RAD51 in lung adenocarcinomas. Clin Exp Pharmacol Physiol. 2022 Jul;49(7):740-747. doi: 10.1111/1440-1681.13646. Epub 2022 May 10. PMID: 35434831. [10]Esfahani MS, Lee LJ, Jeon YJ, Flynn RA, Stehr H, Hui AB, Ish...
The forkhead box protein O3a (FOXO3a) was investigated to mediate the function of U2AF1S34F mutation in cell models using lentivirus. Chromatin immunoprecipitation, immunoblotting analyses, and immunofluorescence assays were also conducted. U2AF1 mutations were associated with poor prognosis in MDS and...
[9]Chen C, Zhou P, Zhang Z, Liu Y. U2AF1 mutation connects DNA damage to the alternative splicing of RAD51 in lung adenocarcinomas. Clin Exp Pharmacol Physiol. 2022 Jul;49(7):740-747. doi: 10.1111/1440-1681.13646. Epub 2022 May 10. PMID: 35434831. [10]Esfahani MS, Lee LJ, Jeon...
KEYWORDS: Myelodysplastic syndromes;Splicing factor U2AF;Spliceosomes;Mutation;Prognosis Corresponding author: Wu Lingyun, Email: moc.3612302ycnil FUNDING: National Natural Science Foundation of China(81670121) COPYRIGHTS: Copyright by Chinese Medical Association No content published by the journals of...
KEYWORDS: Myelodysplastic syndromes;Splicing factor U2AF;Spliceosomes;Mutation;Prognosis Corresponding author: Wu Lingyun, Email: moc.3612302ycnil FUNDING: National Natural Science Foundation of China(81670121) COPYRIGHTS: Copyright by Chinese Medical Association No content published by the journals of...
Clinical implications of U2AF1 mutation in patients with myelodysplastic syndrome and its stability during disease progression[J]. Am J Hematol, 2013,88(11):E277-282. DOI: 10.1002/ajh.23541 . 返回引文位置Google Scholar 百度学术 万方数据 [11] Qian J , Yao DM , Lin J ,et al. U2AF1 ...
Spliceosome mutations are common in myelodysplastic syndromes (MDS) and acute myeloid leukaemia (AML), but the oncogenic changes due to these mutations have not been identified. Here a global analysis of exon usage in AML samples revealed distinct molecu
关键词 急性髓系白血病;U2AF1 基因;基因突变;预后中图分类号 R733. 71 文献标识码 A doi:10. 19746/j. cnki. issn1009 -2137. 2020. 01. 002Clinical Characteristics and Prognosis of U2AF1 Mutation inPatients with Acute Myeloid LeukemiaZHAO Ting-Yuan △ ,GUAN Li-Xun △ ,ZHENG Wen-Shuai △ ,...
Results Amongthe690patientswithAML,therateofU2AF1mutationwas5 5%,whichwasoftenassociatedwithgene mutationssuchasASXL1,NRAS,SETBP1andsoon.ComparedwithU2AF1withoutmutationgroup,U2AF1mutationgroup hadlowerperipheralwhitebloodcellcount(WBC)andbonemarrowblastrate,moderateprognosis,morebadkaryotypesand more+8karyotype...
Clinical features and prognostic analysis of myelodysplastic syndromes patients with U2AF1 mutation Hou Chang Jiang Shuhui Shen Hongjie Ding Zixuan Miao Miao Chen Suning Xu Yang Wu Depei Authors Info & Affiliations Published: 2020 -01 -14 · DOI: 10.3760/cma.j.issn.0253-2727.2020....