Prothrombin 20210 (Factor II) Gene MutationJoel L. Moake, MD
Targeting wild-type and mutationally activated FGFR4 in rhabdomyosarcoma with the inhibitor ponatinib (AP24534). PLOS ONE 8, e76551 (2013). CAS PubMed PubMed Central Google Scholar Gonzalez-Ericsson, P. I. et al. Genenomic landscape of breast cancers with FGFR1 amplification and FGFR1/CCND1...
Votoplam: 一种HTT基因调节剂、splicing factor调节剂药物,由PTC Therapeutics, Inc. (PTC Therapeutics, Inc.)公司最早进行研发,目前全球最高研发状态为临床2期,作用机制: HTT基因调节剂,splicing factor调节剂(剪接因子调节剂),治疗领域: 神经系统疾病,遗传病与畸形,
We treated Calu-3 cells with IFN-β (500 U/ml), harvested cells at different time points, and isolated RNA followed by RT-qPCR to determine changes in SERINC gene expression. We found that the transcription levels of all SERINC genes examined (SERINC1, 2, 3, and 5) were unaffected...
A new human hereditary amyloidosis: the result of a stop-codon mutation in the apolipoprotein AII gene Genomics, 72 (2001), pp. 272-277 View PDFView articleView in ScopusGoogle Scholar 5. M.B. Pepys, P.N. Hawkins, D.R. Booth, et al. Human lysozyme gene mutations cause hereditary syst...
suggested that silencing of GmMYB-G20-1 changes the flower color from purple to grey/blue and that GmMYB-G20-1 may correspond to the W2 gene [60]. Maloney et al. reported the effect of flavonols on the development of tomato pollen. The mutation of the tomato F3H gene resulted in ...
We have previously stated that patients who are diagnosed with stage I/II EC and FGFR2 mutations have shorter DFS. The noticeably reduced PFS observed in such patients after initial surgical treatment has been attributed to the FGFR2 mutation-positive EC’s greater capacity to produce ...
In general, but not always, the level of Factors VIII and IX correlate with bleeding risk. However it should be remembered that someF8gene mutations are associated with discrepant Factor VIII levels depending upon how the Factor VIII is measured - see2-stage FVIII assaysandChromogenic FVIII assay...
inhibit the growth of breast cancer cells with the HER2 gene mutation. The molecular weight of rec EGF is approximately 25 kDa and is composed of 165 amino acids. Recombinant EGF can be used in immunoassays, as a model system for studying biological properties, or as an antibody production ...
Importantly, YY2-regulated gene transcription, cell proliferation and tumor growth were dependent, at least partially, on YY2 K247 methylation. Finally, somatic mutations on YY2 found in cancer, which are in close proximity to K247, altered its methylation, DNA-binding activity and gene ...