The SRF gene promoter has recently been characterized and shown to be autoregulated (116). Mutation of the mouse SRF promoter identified a region between –322 and + 229, relative to the transcription start site, that was essential for basal and inducible SRF transcription. Within this region...
Drug resistance remains a challenge for targeted therapy of cancers driven by EML4-ALK and related fusion oncogenes. EML4-ALK forms cytoplasmic protein condensates, which result from networks of interactions between oncogene and adapter protein multimers
E7090 also increased Cxcl10 in culture sup and expressions of MHC class I and PD-L1 on cell surface of 4T1-Luc cells. In addition to type I IFN-response, we found that LEN and E7090 might regulate ICD evidenced by increased expression levels of cell surface CRT, and Len increased ...
A very recent report demonstrated that the ARID1A gene mutation, which is closely associated with the malignancy of CCC cells, results in downregulation of the mevalonate pathway responsible for cholesterol biosynthesis [111]. This experimental evidence raises the possibility that TF on the...
In a previous report, Cra positively controlled the expression of the crp gene [37], while mdh and fumB were activated by CRP [38]. Fig. 6 Effect of Cra mutation on the relative expression levels of genes (a) and the activities of enzymes (b) involved in succinate biosynthesis. Central...
Inflammatory bowel disease was defined as at least 2 claims of International Classification of Diseases, Ninth Revision (ICD-9) diagnosis codes (CD, 555.xx; UC, 556.xx) or Tenth Revision (ICD-10) diagnosis codes (CD, K50.x; UC, K51.x). To distinguish between UC and CD, the disease...
No increases in HIF target gene mRNA were observed, contrasting with results from RCC10 and RCC4 (Figure 2). Data are presented as the mean of three independent experiments. (B) The 786-O cells were infected with retrovirus-encoding HIF-1a in which the two prolyl residues that are targets...
Minde J, Toolanen G, Andersson T, Nennesmo I, Remahl IN, Svensson O, Solders G (2004) Familial insensitivity to pain (HSAN V) and a mutation in the NGFB gene. A neurophysiological and pathological study. Muscle Nerve 30(6):752–760. https://doi.org/10.1002/mus.20172 Article PubMed...
hyopneumoniae, which has a small AT-rich genome similar to phytoplasmas, no obvious –35 promoter elements were identified upstream of the TSSs of each gene, while the typical –10 promoter elements (5′-TATAAT-3′) were found35. Thus, sweiqthuepnrceevifoeuatsuorebsseorfvathtieonRspoofDoOtY...
Mutation or deletions in Smad genes can also be an important factor during tumor development. Most commonly mutations are seen on Smad4 and Smad2, due to allelic loss or LOH that has been demonstrated in up to 60% of CRCs. Mutations in Smad4 gene (16–25%) and Smad2 gene (6%) have ...