2020年3月11日，清华大学沈晓骅团队在Nature杂志上在线发表了题为 “U1 snRNP regulates chromatin retention of noncoding RNAs”的研究论文，首次揭示U1 snRNP广泛调控非编码RNA在染色质上的结合和移动的新机制。 作者首先建立和运用一套新颖的mutREL-seq方法来高精度筛选调控RNA定位的关键序列，意外发现了U1 snRNP识...
综上,作者提出如下模型:5’和3’剪接位点在lncRNA上的不对称分布,致使U1 snRNP持续结合在lncRNA转录本上,而不能通过RNA剪接过程释放,从而介导了lncRNA的染色质滞留。磷酸化Pol II进一步介导了lncRNA-U1 snRNP复合体在染色质上的移动(mobilization)。对于大多数低丰度、不稳定的lncRNA,它们只能靶向结合邻近的染色质...
对于大多数低丰度、不稳定的lncRNA,它们只能靶向结合邻近的染色质区域(顺式cis作用);而对于少数稳定和高丰度的lncRNA,如Malat1,U1 snRNP促进了其迁移和结合更多的靶基因区域(反式trans作用)。 该工作不仅揭示了U1 snRNP介导非编码RNA在染色质上功能和调控的新模式,而且拓宽了U1 snRNP这一被广泛研究的小核糖核蛋白...
van den Hoogen FHJ, van de Putte LBA (1996) Anti-U1snRNP antibodies and clinical associations. In: van Venrooij WJ, Maini RN (eds), Manual of Biological Markers of Disease, pp C3.1, 1-8, Kluwer Academic Publishers, Dordrechvan den Hoogen FHJ, van de Putte LBA (1996) Anti-U1snRNP...
Anti-U1 snRNP C (U1C) antibody, Rat monoclonal has been used for: immunoblotting immunofluorescence immunoprecipitation immunocytochemistry 生化/生理作用 The U1 small nuclear ribonucleoprotein particle (snRNP) has an important function in the early formation of the spliceosome, the multicomponent complex ...
KLH-conjugated peptide, derived from Arabidopsis thaliana U1 snRNP, UniProt: Q39244 TAIR: At2g47580 来源宿主 兔 反应性 拟南芥 保存建议 Store lyophilized/reconstituted at -20 其他 Agrisera公司提供1000种用于植物和藻类细胞生物学研究的一抗,2000多种二抗。Agrisera公司提供的植物领域的抗体涵盖拟南芥、莱茵衣...
Clinical manifestations and anti-(U1)snRNP antibodies: a prospective study of 29 anti-RNP antibody positive patients. Br J Rheumatol 1992, 31, 811–817. PubMed Google Scholar Nimelstein, S.H., Brody, S., McShane, D., Holman, H.R. Mixed connective tissue disease: a subsequent evaluation...
The removal of introns by the spliceosome is a key gene regulatory mechanism in eukaryotes, with the U1 snRNP subunit playing a crucial role in the early stages of splicing. Studies in metazoans show that the U1 snRNP also conducts splicing-independent f
Anti-U1 snRNP C (U1C) antibody, Rat monoclonal has been used for: immunoblotting immunofluorescence immunoprecipitation immunocytochemistry Biochem/physiol Actions【生化/生理作用】 The U1 small nuclear ribonucleoprotein particle (snRNP) has an important function in the early formation of the spliceosome, ...
2020年3月11日,清华大学沈晓骅团队在Nature杂志上在线发表了题为 “U1 snRNP regulates chromatin retention of noncoding RNAs”的研究论文,首次揭示U1 snRNP广泛调控非编码RNA在染色质上的结合和移动的新机制。 作者首先建立和运用一套新颖的mutREL-seq方法来高精度筛选调控RNA定位的关键序列,意外发现了U1 snRNP识别...