The Wiscott-Aldrich syndrome protein, WASP, is an effector through which cdc42, a Rho family GTPase, regulates the actin cytoskeleton in hematopoietic cells. We have found that WASP binds readily to a number of tyrosine protein kinases including the Src kinases and the Abl kinase when the ...
Examples of nonreceptor protein-tyrosine kinases include src protein kinase (a proto-oncogene) and Jak (Janus kinase). The actions of the insulin receptor protein-tyrosine kinase include stimulation ofmembrane transport, glycogen synthesis, lipogenesis, and protein synthesis, and inhibition of li...
Protein Tyrosine Kinase/RTK——Src(64) Cat. No.Product NameCAS No.PurityChemical Structure KM84571-Naphthyl PP1 1-Naphthyl PP1 (1-NA-PP 1) 是一种选择性的src家族激酶抑制剂。1-Naphthyl PP1 抑制 v-Src 和 c-Fyn,c-Abl,CDK2 和CAMK II,IC50分别为 1.0,0.6,0.6,18 和 22 μM。
蛋白酪氨酸激酶(protein tyrosine kinase,PTK)是一类催化ATP上γ-磷酸转移到蛋白酪氨酸残基上的激酶,能催化多种底物蛋白质酪氨酸残基磷酸化,在细胞生长、增殖、分化中具有重要作用。迄今发现的蛋白酪氨酸激酶中多数是属于致癌RNA病毒的癌基因产物,也可由脊椎动物的原癌基因产生。蛋白酪氨酸激酶在信号转导途径中发挥重要...
In a previous study (K.-I. Sato et al., 1999, Dev. Biol. 209, 308-320), we presented evidence that a Src-related protein-tyrosine kinase (PTK), named Xyk, may act upstream of the calcium release in fertilization of the Xenopus egg. In the present study, we examined whether PTK ac...
The crystal structure of the porcine heart catalytic subunit of cAMP-dependent protein kinase in a ternary complex with the MgATP analogue MnAMP-PNP and a ... Bossemeyer,R A,Engh,... - 《Embo Journal》 被引量: 746发表: 1993年 Conformational Coupling across the Plasma Membrane in Activation...
one of which is protein tyrosine kinases (PTKs).1PTKs are a class of proteins with tyrosine kinase activity whose function is tightly regulated in normal cells. Perturbation of PTKs function by mutations and other genetic alterations can lead to malignant transformation1,2. Previous studies have sh...
PKA protein kinase A PKC protein kinase C PLCγ phospholipase Cγ PLD phospholipase D PMA phorbol-12-myristate-13-acetate PMCA plasma membrane Ca2 +-ATPase PP2A/C phospho-protein phosphatases 2A/C PSD95 postsynaptic density protein 95 PTP1B protein-tyrosine phosphatase 1B PTPα protein-tyrosine...
Introduction: Previous studies report the non-receptor protein tyrosine kinase, Src, to be overexpressed in at least 70% of pancreatic adenocarcinomas. Using the ARIOL imaging system, a computer program that assigns a numerical value to protein staining, we were able to objectively confirm Src overe...
WhenBruton's tyrosine kinase(Btk) was identified as the gene defective in the human immunodeficiency disease X-linked agammaglobulinaemia (XLA) in 1993, this was the first evidence for the involvement of aprotein tyrosine kinaserelated to the Src-family of oncogenic proteins in ahuman geneticdise...