Overexpression of active forms of DmSrc in the developing eye induces the differentiation of increased numbers of photoreceptors, and overexpression of a kinase-inactive mutant interferes with photoreceptor commitment or differentiation. DmSrc activity has been detected using immunoprecipitates prepared with ...
Cantley LC, Auger KR, Carpenter C, Duckworth B, Graziani A, Kapeller R, Soltoff S. Oncogenes and signal transduction. Cell 64:281–302;1991. Article PubMed Google Scholar Chang CM, Shu HK, Kung HJ. Disease specificity of kinase domains: The src-encoded catalytic domain converts erbB ...
An essential role of ubiquitination in Cbl-mediated negative regulation of the Src-family kinase Fyn Signal Transduct., 2 (2002), pp. 29-39 View in ScopusGoogle Scholar [97] N. Rao, A.K. Ghosh, S. Ota, P. Zhou, A.L. Reddi, K. Hakezi, B.K. Druker, J. Wu, H. Band The no...
Identification of Protein-tyrosine Phosphatase 1B as the Major Tyrosine Phosphatase Activity Capable of Dephosphorylating and Activating c-Src in Several H... c-Src tyrosine kinase activity is elevated in several types of human cancer, and this has been attributed to elevated c-Src expression level...
Here we show that the Src-related Yes tyrosine kinase, rather than Src, is localized at endothelial cell (EC) junctions where it becomes activated in a flow-dependent manner. EC-specific Yes1 deletion suppresses VE-cadherin phosphorylation and arrests VE-cadherin at EC junctions. This is ...
to osimertinib resistance.35Bruton tyrosine kinase (BTK) TKIs like ibrutinib, acalabrutinib, and zanubrutinib, constitute another class of covalent inhibitors. They irreversibly and covalently bind to the C481 site of BTK. Therefore, drug resistance can occur in the presence of C481 mutation.64...
The hematopoietic cell kinase Hck is a Src family tyrosine kinase expressed in cells of myelomonocytic lineage, B lymphocytes, and embryonic stem cells. To... R Shivakrupa,V Radha,C Sudhakar,... - 《Journal of Biological Chemistry》 被引量: 110发表: 2003年 Mercuric chloride induces increases...
Chen J, Heller D, Poon B, Kang L, Wang LH: The proto-oncogene c-roscodes for a transmembrane tyrosine protein kinase sharing sequence and structural homology withsevenlessprotein ofDrosophila melanogaster. Oncogene 6:257–264;1991. PubMedGoogle Scholar ...
Protein Tyr kinase Lyn is a member of SRC-related family found in hematopoietic cells (macrophages, platelets, and B lymphocytes). The TEC kinases are also expressed in many hematopoietic cells. In fibroblasts in particular, using the TEC-homology domain, TEC binds to Lyn kinase. The latter th...
The assays may be carried out using the protein tyrosine kinases Lck, Fyn, Lyn, Hck, Fgr, Src, Blk and Yes. The particular protein tyrosine kinase of interest is incubated in kinase buffer (20 mM MOPS, pH7, 10 mM MgCl2) in the presence of the test compound. The reaction is initiated...