Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell lung cancer. Ann Oncol. 2011;22(1):235-7.Garassino MCMM, Rusconi P et al (2011) Different types of K-Ras mutations could affect drug sensitivity and tumour behaviour in non-small-cell ...
(adenocarcinoma vs. squamous cell carcinoma) and mutational state of the protein, C-K-RAS (KRAS) and the epidermal growth factor receptor (EGFR) gene. When considering the whole cancer genome, taking into consideration the preponderance of DNA alteration or specific mutations is the key to ...
What kinds of mutations in the Ras gene could produce an inhibited Ras protein? I. Mutations that decrease the ability of Ras to hydrolyze GTP. II. Mutations that prevent Ras from binding to Ras-GEF. III. Mutations that stimulate Ras to bind to the Ras ...
When it comes to gene insertions or deletions of a single base pair, namely point mutations, the RAS gene family (HRAS, KRAS, NRAS) is associated with malignancies like colon, lung, or pancreatic cancer. These specific point mutations enable researchers to optimally study a multi-layered ...
There are a number of ways to become a cancer, and with genomic instability, the cancer can go in many different directions in terms of which mutations it’s going to pick up to become a cancer. There are a number of subtypes within triple-negative breast cancer that we still don’t ...
The energy for nuclear transport is provided by the small Ras family GTPases. Ran is the most abundant member of the Ras superfamily of GTPases, constituting about 0.4% of the total cell protein [50]. Ran functions as a molecular switch and undergoes a conformational change between the GDP...
Private neoantigens are somatic variants unique to an individual’s tumor and represent the majority of mutations that arise during cancer progression1. Shared neoantigens recur across many patients due to common oncogenic mutations in proteins such as KRAS, EGFR, TP53 and BRAF2,3. Prior knowledge...
of GBM cells are unclear. Here, we show that induction of somatic mutations in subventricular zone (SVZ) progenitor cells leads to the dysregulation of ASCL1 and OLIG2, which then function redundantly and are required for brain tumor formation in a mouse model of GBM. Subsequently, the ...
The vocal fry register, enabling powerful and highly air-efficient echolocation clicks, is used by a diverse group of marine animals, including sperm whales and porpoises.Poikiloderma with neutropenia (PN) is characterized by hematopoietic failure, which originates from mutations in the 3' to 5' ...
Colorectal cancer (CRC) is the third most prevalent cancer and the second most frequent cause of cancer-related deaths worldwide [1]. Previous studies have suggested that the onset of CRC results from the accumulation of mutations in genes controlling key signaling pathways, such as RAS-MAPK, ...