Studies have shown that the prevalence of RAS and BRAF mutations may differ by tumor sidedness among metastatic colorectal cancer (mCRC) patients. Both mutation status and tumor sidedness may impact survival and
High prevalence of ras mutations in sporadic medullary thyroid carcinomaV., SykorovaS., DvorakovaE., VaclavikovaT., HalkovaA., RyskaR., KodetD., KodetovaJ., AstlJ., BetkaJ., Duskova
BMC Cancer (2022) 22:1142 https://doi.org/10.1186/s12885-022-10235-w RESEARCH Open Access Prevalence and patterns of mutations in RAS/RAF/MEK/ERK/MAPK signaling pathway in colorectal cancer in North Africa Meryem Jafari1,2*, Abdelilah Laraqui1, Walid Baba1,2, Soukaina...
Further structural studies revealed a lack of pockets on the surface of wild-type KRAS that would allow binding of small molecules to potentially inhibit its activity [25], [35], [36]. 3. Epidemiology of KRAS-activating mutations: incidence and biology in advanced NSCLC KRAS mutations occur ...
Rising burden of gout in the UK but continuing suboptimal management: a nationwide population study. Ann. Rheum. Dis. http://dx.doi.org/10.1136/annrheumdis-2013-204463. Sicras-Mainar, A., Navarro-Artieda, R. & Ibanez-Nolla, J. Resource use and economic impact of patients with gout: a...
RAS mutations were not identified in any benign papillary lesions. Interestingly, among the 10 carcinomas, only 3 PIK3CA/AKT pathway mutations were identified. The carcinoma with an AKT1 mutation (case 86) had a background of papilloma, as shown by focal residual myoepithelial cells on p63 and...
The frequency ofTP53mutations – highest of all cancer genes, standing at 37% in The Cancer Genome Atlas (TCGA) cohort – indicates that most cancers benefit from the loss ofTP53. However, there are nonetheless many tumors which do not bear a mutation inTP53. A part of those is explained...
Mutations of bial- lelic sites in either PCCA or PCCB genes or compound heterozygous mutations in two genes result in the loss of PCC activity and lead to abnormal accumulation of propi- onyl-CoA and its metabolites, such as propionylcarnitine, propionylglycine, 3-hydroxypropionate and 2-...
Matrix of the altered genes colored by types of mutations. Each column stands for an individual cancer patient (#1–6 for discovery set and #7–28 for validation set), and each row denotes a gene. The right bar graph represents the number of samples with mutations for each gene in the ...
Female genital schistosomiasis, human papilloma virus infection, and cervical cancer in rural Madagascar: a cross sectional study. Infect Dis Poverty. 2023;12(1):89. https://doi.org/10.118 6/...