KEYTRUDA is an anti-programmed death receptor-1 (PD-1) therapy that works by increasing the ability of the body’s immune system to help detect and fight tumor cells. KEYTRUDA is a humanized monoclonal antibody that blocks the interaction between PD...
Long hydrocarbon ligands help in stabilizing the concentrated nanoparticle solutions which help in keeping the nanocrystals suspended in solution. Since carrier recombination deteriorates the device performance due to the trap states present, engineering the nanocrystal surface chemically can better passivate ...
In principle, the differential dynamics of a protein perturbed by various ligands should be able to reflect ligands' different functions. However, in the field of G protein-coupled receptor (GPCR), the phenomenon of conformational heterogeneity, i.e., the sharing of conformations traversed by ...
It was noticed that the ligands TNF and IFN-γ from CD8+ T cells were outstandingly highly correlated with a few target markers on macrophage cells, including the M2 markers CXCR4 and CCL2 (Figure 6G). Considering that TNF and IFN-γ were relatively high in pre-treatment CD8+ T cells ...
To date, secreted CRPs have been mainly reported as ligands of receptors or other cell surface proteins, such as LUREs and RALFs in Arabidopsis45–48, and ES1-4 in maize49. It thus appears very likely that ZmPRP3 affects pollen tube growth after ligand-receptor binding. The fact that ...
Many types of VSCCs have been found in neurons (T, N, L, and P), but uncertainty remains about which ones are involved in neuronal excitation-secretion coupling. Specific ligands for the L- and N-type VSCCs were used to determine which of these subtypes might be involved in the K+-...
7790380 Kits for multiplexed nucleic acid analysis by capture of single-stranded DNA produced from double-stranded target fragments September, 2010 Yang 7749774 Arrays formed of encoded beads having ligands attached July, 2010 Seul 7737088 Method and device for producing biochemical reaction supporting...
Sialyl lewis A (sLea) and sialyl lewis X (sLex) are selectin ligands that aid tumour cell adhesion to endothelia, platelets and leukocytes. sLea/x over-expression is an important event leading to metastasis. A critical component of sLea antigen synthesis is ST3Gal-III. Important to the ...
The hallmark of canonical Wnt signaling is translocation of β-catenin from the cytoplasm to the nucleus. Wnt ligands, such as Wnt3A, bind to a coreceptor complex consisting of the Frizzled (Fz) receptor and low-density lipoprotein receptor-related protein 5 (LRP5) or LRP6. This subsequently ...
At least some of the functions of the CD molecules have been determined. For instance, the integrin complexes and their ligands are well characterized.19 CD49a/CD29 (α1β1), whose ligand is laminin, is present only on stromal cells. CD49b/CD29 (α2β1), whose ligand is collagen, ...