(iv) There are no other ligands within 8 Å around the mapped ligand in the apo structure. Only the single chain receptors in the LP-Set were used to find the apo structures. The only reason for using the single chain receptors was to simplify the process of identifying homologues and ...
Decision trees versus support vector machine for classification of androgen receptor ligands 1 1Presented at CMTPI 2007: Computational Methods in Toxicology and Pharmacology Integrating Internet Resources (Moscow, Russia, September 1–5, 2007). View all notes PreviewView full textDownload full text Acce...
A CLASSIFICATION OF PEPTIDE LIGANDS BASED ON THEIR PREDICTED RECEPTOR CONFORMATIONinformation to stimulate not only the physiological receptor but components important in other aspects of peptide biochemistry, including bio- synthesis, transport to site of release, storage, transport to site of action and...
For example, integrins on floating cells such as leukocytes and platelets are usually inactive; they need to be `activated' by various stimuli prior to displaying the binding to their extracellular ligands 6, 7, 8. Such activating stimuli include activation of protein kinase C [9], cross-...
110. Campbell NH, Smith DL, Reszka AP, Neidle S, O'Hagan D: Fluorine in medicinal chemistry: beta-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Org Biomol Chem 2011, 9(5):1328–1331. 111. Schultze P, Smith FW, Feig...
Inset of the photo showing the Cu9S5 NCs dispersed into different solvents (H2O and CHCl3) before and after the ligands' exchange.45 (b) Experimental design for the synthesis of Fe3O4@Cu2 − xS core-shell nanostructures. (c) Photograph of the tumor-bearing mouse (marked by a dashed ...
All proteins were divided onto seven different functions (protein target classes): transcription factors (TFs), receptors, ligands, kinases, proteases, phos- phatases and metabolic enzymes. The expected number of interactions for a given protein with (for interconnected)/ within (for intraconnected)...
A three-step adjuvant therapy involving FMS-like tyrosine kinase 3 ligands injection, local tumour irradiation, and Toll-like receptor (TLR) agonists injection showed durable regressions of local and distant tumours in lymphoma. Combining adjuvants like TLRs, Nod-like receptors (NLRs), retinoic acid...
Elucidating the specific ligands and targets responsible for the observed activation will require further work. Nonetheless, should nociceptor activation by serum differ between healthy volunteers and patients with neuropathic or inflammatory pain, serum-dependent activation could be used as a physiological ...
Sánchez-Mateos P et al., Regulatory role of CD43 leukosialin on integrin-mediated T-cell adhesion to endothelial and extracellular matrix ligands and its polar redistribution to a cellular uropod. Blood. 1995;86:2228-39. Seethala RR et al., The selective expression of CD43 in adenoid cystic...