-sensitive linker; And design and/or design an antibody-drug conjugate (ADC) in which two types of drug-linker conjugates are linked so that the drug-linker conjugate (B) of the non-camptothecin-based cytotoxic drug and the enzyme-sensitive linker combination is each bound to one antibody. ...
W. et al. LRRC15 is a novel mesenchymal protein and stromal target for antibody–drug conjugates. Cancer Res. 78, 4059–4072 (2018). Article CAS PubMed Google Scholar Korsunsky, I. et al. Cross-tissue, single-cell stromal atlas identifies shared pathological fibroblast phenotypes in four ...
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These differences were not easily accounted for by simple differences in the abundance of the preferred nucleophile for each isotype on a given surface constituent, nor were they due to the preferential binding of one isotype to the sensitizing antibody. We speculate that nascent C4B may contain a...
Drug conjugates, especially antibody drug conjugates (ADCs), have attracted widespread attention for their clinical outcomes and potential commercial value. And the technological advances have led to the intertwined collision of old and new ideas of drug conjugates, which have even challenged the ...
Methods of using the anticancer peptide conjugates to treat cancer are also described.
These techniques look to solve traditional drug delivery challenges, such as poor cellular uptake and/or non-specific toxicity.Bob FornerJoe GuilesSpeciality chemicalsForner B, Guiles J. Peptide-drug conjugates: Types, utility & manufacturing[J/OL]. Speciality Chemicals Magazine, 2012, 32: 46-47 ...
In general, any type of protein lipidation can be detected if a suitable pan-antibody is available; (C–E) ABE and similar methods. These methods are used for detecting S-pamitoylation; (F) Click chemistry. Protein lipidations that can react with specific alkynyl/azide-lipid probes can be...
Invasive GBS infections in neonates rely on the maternal antibody titer. Baker and Kasper (1976) [60] showed an inverse correlation between increased susceptibility of newborns to invasive GBS infections and the circulating serotype-specific capsular antibodies of their mothers. However, unconjugated CPS...
For example, an LBA would not provide theunique data requirements necessary for the establishment of DARs (Drug-Antibody Ratios) for Antibody-DrugConjugates (ADCs). Many of these data requirements are met by th...