antibody–drug conjugatetargeted deliverycancer therapycombination therapyLiu, XinyuDepartment of Biomedical Engineering, School of Medicine Tsinghua University Beijing PR ChinaGao, WeipingDepartment of Biomedical Engineering, School of Medicine Tsinghua University Beijing PR China...
In: Olivier KJJ, Hurvitz SA, eds. Antibody-Drug Conjugates. Hoboken, New Jersey: John Wiley & Sons, Inc., 2016:1-32.Lambert JM. Typical antibody-drug conjugates. In: Olivier Jr KJ, Hurvitz SA, editors. Antibody-drug conjugates: fundamentals, drug development, and clinical outcomes to ...
Monica WhitmireAlan Breau
antibody‐drug conjugateslysosomesreceptor internalizationresistant cell populationsMack, MichelleOncology Research Unit World Wide Research and Development, Pfizer Inc. Pearl River NY USAKahler, JenniferOncology Research Unit World Wide Research and Development, Pfizer Inc. Pearl River NY USAShor, Boris...
Li X, Fang T, Boons G-J (2014) Preparation of well-defined antibody- drug conjugates through glycan remodeling and strain-promoted azide- alkyne cycloadditions. Angew Chem Int Ed 53:7179-7182Li, X.; Fang, T.; Boons, G.J. Preparation of well-defined antibody-drug conjugates through ...
antibody–drug conjugates; antibodies; targeted therapy; cancer immunotherapy; internalization; engineering Graphical Abstract 1. Introduction Antibody–drug conjugates are an actively growing class of precision immunotherapy that has reached clinical and regulatory milestones. Currently, there are fourteen FDA-...
antibody–drug conjugates; cancer; targeted therapy; monoclonal antibody; linker; cytotoxic payload; efficacy; safety; clinical trials 1. Introduction Even though the first anticancer agents were introduced into therapy in the 1940s, today, around 80 years later, cancer remains a serious disease ...
An emerging anticancer treatment, Antibody–Drug Conjugates (ADCs), utilises this unique feature to kill cancerous cells. ADCs consist of an antibody linked with a cytotoxic payload, mainly targeting the antigen found on cancerous cells. This design can increase the specificity in delivering the ...
Pharmaceutics 2024, 16(7), 890; https://doi.org/10.3390/pharmaceutics16070890 ActionDateNotesLink article xml file uploaded 2 July 2024 11:03 CEST Original file - article xml uploaded. 2 July 2024 11:03 CEST Update https://www.mdpi.com/1999-4923/16/7/890/xml article pdf uploaded. 2 Ju...