系统标签: antibody drug conjugates toxin labeled monoclonal Antibody-DrugConjugates(ADCs)ApplicationNoteNT-MO-025Studyingtheinteractionoftheantibody-drugconjugateSYD985withananti-toxinantibodyMoranJerabek-Willemsen1,DavidEgging21NanoTemperTechnologiesGmbH,Munich,Germany2SynthonBiopharmaceuticalsB.V.AbstractAntibody-drug...
《Antibody-Drug Conjugates for the Treatment of Cancer》.pdf Chem Biol Drug Des 2013; 81: 113–121 Special Issue-Review Cancer Treatment and Personalized Medicine Antibody-Drug Conjugates for the Treatment of Cancer 1 1 powerful cytotoxic agent to a tumor cell has the potential John A. Flygare...
Antibody-DrugConjugatesfortheTreatmentofCancer JohnA.Flygare 1 *,ThomasH.Pillow 1 andPaul Aristoff 2 1 DepartmentofDiscoveryChemistry,Genentech,Inc.,1 DNAWay,SouthSanFrancisco,CA94080,USA 2 AristoffConsulting,LLC,Dexter,MI43180,USA *Correspondingauthor:JohnFlygare, flygare.john@gene Withover20...
Antibody–drug conjugates (ADCs) combine the specificity of monoclonal antibodies with the potency of highly cytotoxic agents, potentially reducing the severity of side effects by preferentially targeting their payload to the tumour site. ADCs are being increasingly used in combination with other agents,...
【英美经典书籍】《Antibody-Drug Conjugates: Methods in Molecular Biology》【已搜索,无重复】 作者:Laurent Ducry 出版社:Humana Press 出版时间:2013 Language: English ISBN-10: 1627035400 ISBN-13: 978-1627035408 页码:329 页 文件格式:PDF 文件大小:5 MB 书籍简介: . Antibody-drug conjugates (ADCs) ...
Antibody-drug conjugates 下载积分:3000 内容提示: 42 Pharmaceutical Technology January 2012 PharmTech.comIn the quest for more targeted thera-pies and potentially more clinically efficacious drugs, bio/pharmaceutical companies are increasing their research and product development in biologics. Although the ...
conjugates, which consist of hydrophilic and hydrophobic payloads conjugated to two different antibodies, retain the structure and binding properties of the antibody and its biological specificity, are stable in plasma and improve anti-tumour efficacy in mice with non-small cell lung tumour xenografts....
United States Patent US11596693 Note: If you have problems viewing the PDF, please make sure you have the latest version ofAdobe Acrobat. Back to full text
Antibody-drug conjugates (ADCs) have been recognized as a promising new class of therapeutic agents for the treatment of cancer (1). In the generation of ADCs, cytotoxic small molecules are covalently attached to therapeutic antibodies thereby increasing their specificity towards tumor cells. We have...
There is a need in the art for developing an approach for depleting, inhibiting and/or killing the growth and spread of HAAH-expressing cells involved in cancers. Accordingly, there is a need for anti-HAAH antibody-drug conjugates that are constructed in such a manner so as to be capable ...