Secretin is a large outer-membrane channel found in secretion systems of Gram-negative bacteria, facilitating the last step for transfer of proteins into the extracellular environment. In the type II secretion
[64]. GspD is asecretin familyprotein that multimerizes to form the outer membrane channel, which in some bacteria requires an additional pilotinlipoproteinfor its correct localization and assembly[53,65]. The precise mechanism of secretion by the T2SS machinery has not been fully elucidated...
6. The secretin channel The T2SS component GspD forms a dodecameric, megadalton-size complex in the OM. It is a member of the secretin class of multi-domain proteins that function as OM channels in many Gram-negative secretion machineries [9] (Fig. 2). Domains N3 and C in T2SS secre...
Yan, Z., Yin, M., Xu, D., Zhu, Y. & Li, X. Structural insights into the secretin translocation channel in the type II secretion system. Nat. Struct. Mol. Biol. 24, 177–183 (2017). Article CAS PubMed Google Scholar Py, B., Loiseau, L. & Barras, F. An inner membrane pla...
Production of the type IV secretion system differs among Brucella species as revealed with VirB5- and VirB8-specific antisera. Infect. Immun. 71, 1075–1082 (2003). Article CAS PubMed PubMed Central Google Scholar Baron, C., O'Callaghan, D. & Lanka, E. Bacterial secrets of secretion: ...
The GspD secretin is the outer membrane channel of the bacterial type II secretion system (T2SS) which secrets diverse toxins that cause severe diseases such as diarrhea and cholera. GspD needs to translocate from the inner to the outer membrane to exert its function, and this process is an...
Type II secretion systems (T2SSs) are critical for secretion of many proteins from Gram-negative bacteria. In the T2SS, the outer membrane secretin GspD forms a multimeric pore for translocation of secreted proteins. GspD and the inner membrane protein GspC interact with each other via ...
The type II secretion system (T2SS) secretes enzymes and toxins across the outer membrane of Gram-negative bacteria. The precise assembly of T2SS, which consists of at least 12 core-components called Gsp, remains unclear. The outer membrane secretin, GspD, forms the channels, through which ...
ter membrane protein secretin of type III secretion system of Vibrio vulnificus: structure prediction and orientation Original Research (2816) Total Article Views Authors: Rama Adiga, Iddya Karunasagar, Indrani Karunasagar Published Date February 2011 Volume 2011:3 Pages 61 - 66 DOI: http://dx....
According to the current model (Korotkov et al., 2012), the protein, once folded in the periplasm, interacts with the T2SS inner membrane component GspC, secretin GspD, and is pushed through the pore formed by the secretins to be released into the outer medium. This model cannot explain...