Type II Secretion System Type II secretion systems(T2SS) enable bacteria to translocate proteins into the extracellular environment[63,64].L. pneumophilatransports more than 25 protein substrates through the T2S
type IV pilus systemThe type II secretion system (T2SS) is a multi﹑rotein complex used by many bacteria to move substrates across their cell membrane. Substrates released into the environment serve as local and long‐range effectors that promote nutrient acquisition, biofilm formation and ...
Here we will provide an update on the more recent findings in the field and discuss mechanistic and functional aspects of type II secretion process. 2. T2SS substrates: biogenesis, diversity and biological functions Gram-negative bacteria have developed several strategies to energize protein secretion...
Secretin is a large outer-membrane channel found in secretion systems of Gram-negative bacteria, facilitating the last step for transfer of proteins into the extracellular environment. In the type II secretion system, a lipoprotein called pilotin is essential to bind and target its corresponding secr...
Type IX secretion system (T9SS), exclusively present in theBacteroidetesphylum, has been studied mainly inFlavobacterium johnsoniaeandPorphyromonas gingivalis. Among the 18 genes, essential for T9SS function, a group of four,porK-N(P. gingivalis) orgldK-N(F. johnsoniae) belongs to a co-transcr...
四型分泌系统 (type IV secretion system, T4SS) 是一种在革兰氏阴性菌 、革兰氏阳性菌和古细菌中均广泛存在的多功能、多组分的跨膜通道结构,将DNA,蛋白质或其他大分子递送至靶细菌或真核细胞。与细菌中已发现的其它分泌系统不同,T4SS形成的管道既能通过蛋白质又能通过DNA,因此T4SS能够介导细菌接合转移、DNA释...
相反,有人建议将T4CP放置在T4SS的入口处,将底物直接转移到T4SS。已经提出了针对ssDNA底物的三种可能的转移途径:(i)通过T4CP六聚体的通道转移至T4SS;(ii)在其被T4CP摄取后,底物可以通过VirB4六聚体并从那里转移到T4SS;或(iii)在与ATP酶相互作用后,底物可直接通过IMC亚基形成的通道转移。
VirA, a secreted effector protein from Shigella sp ., has been shown to be necessary for its virulence. It was also reported that VirA might be related to papain-like cysteine proteases and cleave -tubulin, thus facilitating intracellular spreading. We have now determined the crystal structure ...
Several bacterial plant pathogens colonize their hosts through the secretion of effector proteins by a Type III protein secretion system (T3SS). The role of T3SS in bacterial pathogenesis is well established but whether this system is involved in multicellular processes, such as bacterial biofilm forma...
1 ABSTRACT2 The invasion of intestinal epithelial cells by Salmonella enterica serovar Typhimurium is3 mediated by a Type Three Secretion System (T3SS) encoded on Salmonella pathogenicity island4 1 (SPI1). Expression of the SPI1 T3SS is tightly regulated by the combined action of HilC...