Sendai virus infection mobilizes airway cells to form alveolar SOX2+ clusters without differentiating into AT1 or AT2 cells, as shown in influenza models. Intriguingly, large AT2-cell-depleted areas remain covered by AT1 cells, which we name "AT2-less regions", and are replaced by SOX2+ ...
2. Experimental tubercles are formed in the lung, as in the liver, primarily by cells originating in the capillary endothelium. These cells are probably present in small numbers in the normal lung, lying free both in the alveolar ... Foot,C N. - 《Journal of Experimental Medicine》 被引...
Elucidating the mechanisms by which alveolar cell types are maintained and regenerated after injury has important implications for normal respiratory physiology and disease, and for designing regenerative therapies. An important outstanding question, however, is whether type I cells can change their ...
ARTICLE https://doi.org/10.1038/s41467-022-29308-2 OPEN Lung type II alveolar epithelial cells collaborate with CCR2+ inflammatory monocytes in host defense against poxvirus infection Ning Yang 1✉, Joseph M. Luna 2, Peihong Dai1, Yi Wang 1, Charles M. Rice 2 & Liang Deng 1,2,3...
of asthma, allergen exposure increased production of SCF by epithelial cells and alveolar macrophages, which was transient and paralleled by histamine release... Oliveira,HP S.,Lukacs,... - Current Drug Targets - Inflammation & Allergy 被引量: 79发表: 2003年 Targeting...
(a) the epidermis (b) the periosteum (c) linings of the glomeruli in nephrons (d) alveolar cells of the lungs. Which covers both the external and internal free body surface of organisms - the epithelium or the connective tissue? Explain. What are the main cells of connective tissue ...
Type II pneumocytes are smaller, roughly cuboidal cells, usually found at the alveolar septal junctions, responsible for secreting surfactant and will replicate to replace damaged Type I pneumocytes. From: The Dictionary of Cell & Molecular Biology (Fifth Edition), 2013 ...
2.1. Establishment of CALR-Mutated MPN-Model Cells To dissect the transcriptomic discrepancies between type 1 and type 2 CALR-mutated MPN, we aimed to use the IL-3-dependent Ba/F3 (BaF3) cell line to establish MPN cell models, which ectopically expressed respective mutant CALRs. With the ind...
Blood Groups & Transfusions: Blood groups are based on the antigens present on the red blood cell of an individual. Antigens on the red blood cell surface can be recognized by a person's immune system. If an antigen is identified as foreign by the i...
which suggested the roles of alveolar type II (AT2) and club cells for lung adenocarcinoma, basal cells for lung squamous cell carcinoma, and neuroendocrine cells for small cell lung cancer, which are all in the epithelial group of lung cells. Recent single-cell approaches using human and mouse...