Pulmonary AlveoliRespiratory MucosaSodiumNa(+)K(+)交换ATP酶肺泡钠钠通道Despite a presumptive role for type I (AT1) cells in alveolar epithelial transport, specific Na transporters have not previously been localized to these cells. To evaluate expression of Na transporters in AT1 cells, double ...
Do dendritic cells help macrophages activate T-cells by carrying marked pathogens to the T-cells? What are two types of specialized cells in the wall of the alveoli? A single layer of flat tile-shaped epithelial cells ...
Immunoreactivity for 11β-HSD1 was detected in the cytoplasm of the cells in the alveolar region of adult rats. Some of these expressing 11β-HSD1 were considered to be alveolar type Ⅱ cells, because of their cuboid shape and localization at the corner of the alveoli. RT-PCR demonstrated ...
Lung alveoli are lined by alveolar type I cells (AT1) and cuboidal type II (AT2) cells. The AT1 cells are likely to be exposed to cell-free hemoglobin (Hb) in multiple lung diseases; however, the role of Hb redox (reduction-oxidation) reactions and their precise contributions to AT1 cell...
Type I cells form a large, thin epithelial layer that facilitates gas exchange and transport of fluids between the air spaces and capillaries. The T1alpha gene has a complex pattern of developmental expression in lung and brain; in vitro studies indicate that expression is regulated in part by ...
Similarly, a polyclonal pan-cadherin antibody uniformly decorated luminal surfaces of alveoli except the type II pneumocytes. Furthermore, pleural mesothelial cells, bronchiolar epithelial cells, endothelial cells of large blood vessels and alveolar macrophage surfaces exhibited pan-cadherin immunoreactivity. ...
Exogenous addition of rat IL-1alpha to cultured lung fibroblasts induced PGE2 secretion in a dose-response manner. When fibroblasts were cocultured with rat ATII cells, IL-1alpha protein was detectable in ATII cells and in the coculture medium between days 8 and 12 of culture, correlating ...
However, the type II cells work in concert with the other cells in the gas exchange regions of the lung to keep the alveoli open and reduce inflammation due to irritants in the air we breathe. 展开 关键词: epithelial cells phospholipids ...
wfdc2−/− neonates had thick alveolar interstitium and decreased number of alveoli. • Expression of type-I cell markers Hopx and T1α were decreased in lungs of wfdc2−/− neonates. • Lung tissues of wfdc2−/− neonates contained fewer blood vessel, caused by increased apoptosi...
Mature alveoli are composed of two major distinct epithelial cell types, type I and type II cells. Type I cells are thin, have a large surface area and lie in close contact with capillaries to facilitate gas exchange; they express podoplanin (Pdpn) and Ager (advanced glycosylation end product...