AT1 cell, alveolar type 1 epithelial cell; AT2 cell, alveolar type 2 epithelial cell. Micrographs in top left, middle and bottom panels are shown without pseudocolouring in Fig. 2g–i. b, c, gCap cells associate with fibroblasts. Alveoli with labelled aerocytes (aCap) in Apln-creER; Rosa...
Cryoscanning electron microscopy of frozen tissue demonstrated surfactant to cover extended areas of alveolar surface as a continuous, thin layer. For methodological reasons, however, this approach was restricted to the outermost subpleural alveoli, and is not applicable to central regions [16]. While ...
In severely injured pulmonary parenchyma MEP-1-negative areas occurred, which were also negative with the type II pneumocyte marker Maclura pomifera lectin. Similarly, a polyclonal pan-cadherin antibody uniformly decorated luminal surfaces of alveoli except the type II pneumocytes. Furthermore, pleural...
The alveoli are lined by cuboid alveolar type 2 cells (AT2) specialized in surfactant secretion, and flat alveolar type 1 cells (AT1) responsible for gas exchange2. In the damaged lung, different epithelial cells can self-renew and differentiate, depending on the region and type of injury18....
Pulmonary AlveoliCapillariesEpithelial CellsCytoplasmAdultMiddle AgedCell CountEight normal human lungs obtained from patients dying from causes not related to the lung were subjected to morphometric analysis to determine the number of cells in the alveolar region and their mean volume and surface ...
Alveoli, the lung's respiratory units, are tiny sacs where oxygen enters the bloodstream. They are lined by flat AT1 cells, which mediate gas exchange, and AT2 cells, which secret surfactant. Rare AT2s also function as alveolar stem cells. We show that AT2 lung stem cells display active Wn...
Mitotic cells were observed randomly distributed within tubulo-alveoli, similar to those in interphase. The first sex differences were observed at day 20, when type II cells appeared in male glands. From this point, the percentage of type II cells rapidly increased in male glands. This incre...
Supplementary Fig.1c, d) (Supplementary Data2). We also compared the lung and gill cell type repertoires, revealing broad cell type similarities as well as organ-specific cell types (e.g., alveolar cells in the lung) (Supplementary Fig.1e). We next focused on cell type annotation and th...
KGF did not activate the c-Jun kinase or p38 MAP kinase pathways. We conclude that the p42/44 MAP kinase and PI3 kinase pathways are important in regulating alveolar type II cell proliferation in response to KGF. 展开 关键词: Animals Rats Pulmonary Alveoli Epithelial Cells Cells, Cultured ...
Damage to alveoli, the gas-exchanging region of the lungs, is a component of many chronic and acute lung diseases. In addition, insufficient generation of alveoli results in bronchopulmonary dysplasia, a disease of prematurity. Therefore visualising the