APOPTOSIS -OXFORD-ThorburnA.Thorburn A. Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis : an international journal on programmed cell death. 2008;13(1):1-9.Apoptosis and autophagy: regulatory connections between two supposedly different processes[J] ....
The detection of Zn2+ has attracted scientific interest as Zn2+ is the second most prevalent transition metal in the body, endowed with outstanding roles in physiological processes.[1], [2], [3], [4] Zn2+ has been related to Alzheimer’s or Parkinson’s diseases and infections such as...
The ontogeny of these splicing events was also examined from tissues of different ages.From this quantitative study, carried out by PCR of reverse-transcribed mRNA, it clearly appears that the observed splicing processes in the IVS3–IVS4 region are not only tissue-dependent but also regulated ...
Globally, this trend persisted; the most strongly and significantly regulated biological processes concerned EPE (Figure 4F; Table S2). We found processes linked to apoptosis to be upregulated, while angiogenesis and blood vessel formation were reduced. These findings are in line with the known ...
Inflammation is a complex biological response to various processes such as infection, tissue injury, cell death, cancer, ischemia, and degeneration [57, 58]. The development of potent PEP inhibitors and anti-inflammatory agents have been attracting growing attentions from both academia and ...
This finding implies that amino acid metabolism plays a crucial role in the response of the cells to a hypoxic environment25. Trp is an essential amino acid that plays a critical role in protein biosynthesis and affects various pathophysiological processes, including neuronal function, metabolism, ...
However, the cellular mechanisms of how caspase-1 is involved in these processes remain poorly defined28. Since both C1RB and C1FS showed excellent two-photon "Turn-ON" properties in response to caspase-1 both in vitro and in an artificial cell model, we used them to image caspase-1 ...
It is as important as Cu1 in cellular copper homeostasis and redox cycling processes of Cu12. Up to now, a few efficient fluorescent sensors for Cu21-selective detection have been reported13–20. We have also developed a ratiometric strategy for intracellular sensing and imaging of Cu21, with...
packed within the nucleus and stably propagate while preventing the DNA from becoming twisted and tangled. Chromatin exists in a default condensed state that restricts the access of biological macromolecules and safeguards the genome. However, there are time- and space-dependent processes that open the...
ATXN2L has a role in regulating processes like apoptosis, so malfunctions in this gene are likely to trigger both rheumatoid arthritis and osteoporosis. MMP14 contributes to building extracellular tissue like cartilage and could be responsible for the breakdown of joint tissue that leads to rheumatoi...