Apoptosis is defined as the process of ''programmed cell death'' (PCD), during which many cells simultaneously die from within along a very orderly pattern. PCD is as intrinsic for cells as mitosis and is involved in both degenerative and developmental processes of organs and organisms. The ...
Apoptosis is the process of natural programmed cell death used to maintain organism homeostasis68. For example, macrophages are the first line of defense against pathogens69,70. They are regulated by apoptosis to maintain immune homeostasis and protect the host against damage from excessive inflammation...
Among the intracellular events of the cells, apoptosis is a process of programmed cell death including various biochemical events such as cell shrinkage, zeiosis, nuclear fragmentation, and chromatin condensation9,10. Highly regulated and controlled biochemical process, apoptosis, is essential to multicel...
Apoptosis--the regulated destruction of a cell--is a complicated process. The decision to die cannot be taken lightly, and the activity of many genes influence a cell's likelihood of activating its self-destruction programme. Once the decision is taken, proper execution of the apoptotic programme...
It is also the most important terminal shear enzyme in the process of cell apoptosis and one of the effectors of nuclear apoptosis. Our results demonstrated that the expression of caspase-3 in the H2O2 group was signifi- cantly higher than that in the normal control group (p < 0:05); ...
Apoptosis, a kind of cell death, causes specific morphological changes and DNA fragmentation that are considered as the major cytopathologic hallmarks of the apoptotic process [15]. Most commonly, two major apoptosis pathways have been identified: the death receptor pathway and the mitochondrial pathwa...
The variations seen force a reassessment of those aspects of physiological cell death that are truly universal, thereby focusing attention on the biology of the process. A better understanding of the biology and morphology of dying cells will help clarify the significance of the molecular and ...
Withdrawal of the cytokine induces apoptosis, whose classic late events are evident after 16/18 hours, and are preceded by a calcium drop during the first 2/3 hours after IL-3 subtraction. Calcium drop is here proposed as a trigger of the apoptotic process, in agreement with other recently ...
For over three decades, a mainstay and goal of clinical oncology has been the development of therapies promoting the effective elimination of cancer cells by apoptosis. This programmed cell death process is mediated by several signalling pathways (referred to as intrinsic and extrinsic) triggered by...
In this work, we have explored the subcellular localization of Bcl2, a major antiapoptotic protein. In U251 glioma cells, we found that Bcl2 is localized mainly in the ER and is translocated to MAM and mitochondria upon induction of apoptosis; this mitoc