The article published in the Blood Cancer Journal on January 9, 2025, explores the role of tunneling nanotubes (TNTs) between bone marrow stromal cells (BMSCs) in supporting transmitophagy and resistance to apoptosis in multiple myeloma (MM) cells within the bone marrow microenvironment. The ...
Cell-to-cell communication coordinates the development of multicellular systems, and is mediated by soluble factors, gap junctions and the recently described tunneling nanotubes (TNT). Both TNT and gap junctions facilitate the transfer of intracellular mediators between the cytoplasm of connected cells. ...
Tunneling nanotubes (TNTs) are essential intercellular communication channels that significantly impact cancer pathophysiology, affecting tumor progression and resistance. This review methodically examines the mechanisms of TNTs formation, their structural characteristics, and their functional roles in material an...
Tunneling nanotubes (TNTs) represent a novel route of intercellular communication. While previous work has shown that TNTs facilitate the exchange of viral or prion proteins from infected to naïve cells, it is not clear whether the viral genome is als
Tunneling nanotubes (TNTs) are intercellular conduits which meet the communication needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred microns. TNTs are unique type of membrane protrusion which contain F-actin and freely hover over substratum in the extra...
Tunneling nanotubes (TNTs), discovered in 2004, are thin, long protrusions between cells utilized for intercellular transfer and communication. These newly discovered structures have been demonstrated to play a crucial role in homeostasis, but also in the spreading of diseases, infections, and metasta...
Recent studies have elucidated the potential role of tunneling nanotubes (TNTs) in this function. TNTs are long, filamentous, actin-based cell protrusions that mediate direct cell-to-cell communication between malignant cells. In this study, we investigated the formation of TNTs in response to ...
Mi L, Xiong R, Zhang Y, Li Z, Yang W, Chen J-Y, et al. Microscopic observation of the intercellular transport of CdTe quantum dot aggregates through tunneling-nanotubes. J Biomat Nanobiotech. 2011;2(2):173-80.Mi L, Xiong R, Zhang Y, Li Z, Yang W, Chen J-Y, et al. ...
Tunneling-nanotubes (TNTs) are a kind of cell-cell communication when cells are under stress. We hypothesize that insulted cells use TNTs as a highway to transfer materials and energy to healthy cells. TNTs transfer cellular compartments, such as endoplasmic reticulum (ER), mitochondria, Golgi...
Antonella Vimercati5, Gabriella Serio6, Karl Frei7, Roberto Perris8 and Daniela Virgintino1* Abstract Background: Nanotubular structures, denoted tunneling nanotubes (TNTs) have been described in recent times as involved in cell-to-cell communication between distant cells. ...