Tumors are heterogeneous tissues that recruit non-cancerous cells to the tumor microenvironment. In the past few years, the paradigm for the intercellular communication within the tumor, mainly based on plasma
Tunneling nanotubes (TNTs) are F-actin-based membrane tubes, and can form between cultured cells and within vital tissues. TNTs mediate intercellular communications that range from electrical signaling to the transfer of organelles. Following peripheral nerve injury, the orchestrated intercellular ...
Ovarian cancerPancreatic cancerIntercellular communication plays a critical role in the ever-evolving landscape of invasive cancers. Recent studies have elucidated the potential role of tunneling nanotubes (TNTs) in this function. TNTs are long, filamentous, actin-based cell protrusions that mediate ...
Tunneling nanotubes (TNTs) are intercellular conduits which meet the communication needs of non-adjacent cells situated in the same tissue but at distances up to a few hundred microns. TNTs are unique type of membrane protrusion which contain F-actin and freely hover over substratum in the extra...
Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular...
A given cell makes exchanges with its neighbors through a variety of means ranging from diffusible factors to vesicles. Cells use also tunneling nanotubes (TNTs), filamentous-actin-containing membranous structures that bridge and connect cells. First des
Tunneling nanotubes (TNTs), discovered in 2004, are thin, long protrusions between cells utilized for intercellular transfer and communication. These newly discovered structures have been demonstrated to play a crucial role in homeostasis, but also in the spreading of diseases, infections, and metasta...
Tunneling nanotubes (TNT) are induced by HIV-infection of macrophages: a potential mechanism for intercellular HIV trafficking. Cell Immunol 2009; 254:142–8; PMID: 18835599; DOI: 10.1016/j. cellimm.2008.08.005. through this mechanism.1 In the past year it has been shown that the virus ...
COMMENTARYTunneling nanotubes: novel potentials for oldplayersEHSAN SARAFRAZ-YAZDIBROOKLYN, NYCell-to-cell communication constitutes acrucial survival element in multicellular or-ganisms, whereby the way by which cellssend and receive signals defines much of their special-izedactivities and development. ...
Zika virus (ZIKV) is unique among orthoflaviviruses in its vertical transmission capacity in humans, yet the underlying mechanisms remain incompletely understood. Here, we show that ZIKV induces tunneling nanotubes (TNTs) in placental trophoblasts which