Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells. Cell Death Differ 2015, 22, 1181-1191, 10.1038/cdd.2014.211.Wang, X.; Gerdes, H.H. Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells. Cell Death Differ. 2015, 22, 1181-1191. [CrossRef]...
TNTs allow the transport of biological cargos, ranging from calcium ions to organelles like mitochondria, between cells present within the tumor. These TNT-mediated connections in tumors have a strong biological significance as they promote tumor progression and resistance to therapy and might also be...
OPEN Cell Death and Differentiation (2015) 22, 1181–1191 & 2015 Macmillan Publishers Limited All rights reserved 1350-9047/15 www.nature.com/cdd Transfer of mitochondria via tunneling nanotubes rescues apoptotic PC12 cells X Wang*,1 and H-H Gerdes1,{ Tunneling nanotubes (TNTs) are F-actin...
The purpose of this study was to investigate the role of tunneling nanotubes (TNTs) as unique intercellular conduits capable of propagating a long-range form of the bystander effect following oncolytic viral infection of cancer cells. TNTs are long, fine, nonadherent actin-based cytoplasmic extensi...
Tunneling nanotubes (TNTs), discovered in 2004, are thin, long protrusions between cells utilized for intercellular transfer and communication. These newly discovered structures have been demonstrated to play a crucial role in homeostasis, but also in the spreading of diseases, infections, and metasta...
There is growing evidence indicating that MSCs donate mitochondria to a variety of cells, including endothelial cells, cardiomyocytes, and epithelial cells, to repair tissue damage [19–21]. The means of mitochondrial transfer involve tunneling nanotubes (TNTs), extracellular vesicles, and cellular ...
The point that mitochondria can be exchanged between TNT connected cells is extremely important because this could be one of the first demonstrations of transfer of genetic material between non-dividing cells, suggesting that at least mitochondrial DNA is not cell type exclusive and can be shared ...
Tunneling nanotubes (TNTs) are actin-based cytoplasmic extensions that directly transfer cellular cargo between connected cells. Intercellular transport of signaling molecules and regulatory RNAs are an integral part of defining the tumor microenvironment and intratumoral heterogeneity. The TNT-based cellular...
demonstrated in an in vivo assay that bone marrow mesenchymal stem cells (BMSCs) can form CX43-dependent tunnels through direct contact with alveolar epithelial cells nanotubes and microvesicles. By transferring mitochondria from BMSCs, alveolar ATP energy was increased to protect alveolar cells, a ...
Cooperation of Various Cytoskeletal Components Orchestrates Intercellular Spread of Mitochondria between B-Lymphoma Cells through Tunnelling Nanotubes Cells, 13 (2024), p. 607, 10.3390/cells13070607 View in ScopusGoogle Scholar 51 M. Wühr, N.D. Obholzer, S.G. Megason, H.W. Detrich, T.J. ...