(2017) alpha-synuclein transfer through tunneling nanotubes occurs in SH-SY5Y cells and primary brain peri- cytes from Parkinson's disease patients. Sci. Rep., 7, 42984.Dieriks BV, Park TI-H, Fourie C, Faull RLM, Dragunow M, Curtis MA. α-synuclein transfer through tunneling nanotubes ...
Tunneling nanotubes (TNTs) have emerged as pivotal structures for intercellular communication, enabling the transfer of cellular components across distant cells. Their involvement in neurological disorders has attracted considerable scientific interest. This review delineates the functions of TNTs within the...
Cells use also tunneling nanotubes (TNTs), filamentous-actin-containing membranous structures that bridge and connect cells. First described in immune cells, TNTs facilitate HIV-1 transfer and are found in various cell types, including neurons. We show that the microtubule-associated protein Tau, ...
Cell Death and Disease (2012) 3, e438; doi:10.1038/cddis.2012.177; published online 6 December 2012 Subject Category: Neuroscience Tunneling nanotubes (TNTs) are described as thin membra- nous and hovering freely channels located between cells.1,2 As a new principle in cell–cell communication,...
Tunneling nanotubes (TNTs), discovered in 2004, are thin, long protrusions between cells utilized for intercellular transfer and communication. These newly discovered structures have been demonstrated to play a crucial role in homeostasis, but also in the spreading of diseases, infections, and metasta...
TNTs are intercellular conduits which meet the communication need of non-adjacent cells situated in same tissue but at distances up to few hundred microns (Fig. 1). TNTs, also called as tumor nanotubes (in case of cancer cells), are analogous to plasmodesmata which connect the cytoplasm of ...
Tunneling nanotubes between rat primary astrocytes and C6 glioma cells alter proliferation potential of glioma cells Abstract The tunneling nanotube (TNT) is a newly discovered, long and thin tubular structure between cells. In this study, we established a co-culture system for rat primary astrocytes...
Cell-to-cell communication is essen for the development of multicellular systems and is coordinated by soluble factors, exosomes, gap junction (GJ) channels, and the recently described tunneling nanotubes (TNTs). We and others have demonstrated that TNT-like structures are mostly present during path...
Zika virus (ZIKV) is unique among orthoflaviviruses in its vertical transmission capacity in humans, yet the underlying mechanisms remain incompletely understood. Here, we show that ZIKV induces tunneling nanotubes (TNTs) in placental trophoblasts which facilitate transfer of viral particles, proteins,...
The purpose of this study was to investigate the role of tunneling nanotubes (TNTs) as unique intercellular conduits capable of propagating a long-range form of the bystander effect following oncolytic viral infection of cancer cells. TNTs are long, fine, nonadherent actin-based cytoplasmic extensi...