The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial.ASCOcoloncancerpathologyprognosticstromaVICTORBackground The intra-tumor stroma percentage in colon cancer (CC) patients has previously been reported by our group as a...
cells were Mac_SPP1in both treatment naïve dMMR and pMMR (Fig.2h). In addition, the proportion of Mac_SPP1was higher in treatment naïve dMMR compared to pMMR, while lower in dPR/CR compared to dSD (Fig.2h, i). Previous reports on the immune cell frequencies in CRC tumors have ...
Therefore, all patients were classified as “stroma-rich” or “stroma-poor” according to the proportion of stroma ≥50% or <50%, respectively. The higher stroma-rich proportions were found in EOC patients with advanced stage, LN metastasis, and recurrence. Tumor tissue is composed of both ...
Analysis was performed using the Cox proportion hazard model. b p < 0.05 was considered significant (indicated in bold). TABLE 3. Multivariate Cox Analysis for 3-Yr Survival in 95 Patients of Esophageal Squamous Cell Carcinoma Empty CellMultivariate Analysisa 3-Yr Overall Survival3-Yr Disease-Fre...
Intratumoral application of artLCMV vectors changed the non-hematopoietic tumor stroma with a significantly increased proportion of PDPN+FSCs (Fig.4a), while the fractions of CD31+blood endothelial cells and PDPN-negative FSCs cells were reduced (Supplementary Fig.4a–c). The stromal cell composition...
The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: Validation in the VICTOR trial. Ann. Oncol. 2013, 24, 179–185. [Google Scholar] [CrossRef] [PubMed] Karpathiou, G.; Vieville, M.; Gavid, M.; Camy, F.; Dumollard, J.M.; ...
and its components and proportion changes inter/intra-personally [2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35]. Patient-derived in vitro models of human cancer were very promising and were supposed to overcome key challeng...
The proportion of tumor-stroma as a strong prognosticator for stage II and III colon cancer patients: validation in the VICTOR trial The intra-tumor stroma percentage in colon cancer (CC) patients has previously been reported by our group as a strong independent prognostic parameter. Pat... A ...
First, to determine the proportion of each cell population residing within ductal or stromal regions, we used regional masks demarcating the epithelium and stroma to quantify the frequency of each cell type in these regions (“tissue compartment enrichment,” Figure 3A; Figure S5A; STAR Methods“...
A key question in understanding the origin of metastasis is how cancer cells in a primary tumor acquire the ability to colonize a particular distant organ. Primary tumors release large numbers of cancer cells into the circulation, yet only a small proportion of these cells survive the stress of...