Tumor–stroma ratioBackground:cT1/2 oral tongue squamous cell carcinoma (OTSCC) often metastasizes to cervical lymph nodes. However, predicting neck lymph-node metastasis (NLM) remains challenging. Pathomorphological evaluation of tumor budding grade (TBG) and tumor-stroma ratio (TSR) reportedly can...
BackgroundTumor-stroma ratio (TSR) represents a percentage of neoplastic component to the combined neoplastic and tumor-associated stromal area. TSR has been demonstrated to be a new prognostic factor in cancers of several organs including the uterine cervix. In cervical cancer, TSR was evaluated ...
Tumor-stroma ratio (TSR) has been identified as a new and practicable prognostic histological characteristic of solid tumors. The aim of this study was to evaluate the prognostic value of TSR in resected esophageal squamous cell carcinoma (ESCC). Methods: A total of 95 patients who underwent eso...
It is the first investigation on the prognostic role of tumor–stroma ratio (TSR) in cervical cancer.TSR was confirmed as an independent prognostic factor for early cervical cancer.Possible application of TSR in clinical and pathologic practice for better classification of patients with early cervical...
The carcinoma-stromal ratio of colon carcinoma is an independent factor for survival compared to lymph node status and tumor stage. Cell Oncol. 2007;29:387–98. PubMed PubMed Central Google Scholar Liu J, Liu J, Li J, et al. Tumor-stroma ratio is an independent predictor for survival ...
A mechanistic study showed that miR-141 targeted YAP1, a critical effector of the Hippo pathway, reducing the nuclear YAP1/TAZ ratio and enhancing GROα production from stromal fibroblasts. Stromal-specific knockout (cKO) of Yap1 in murine models shaped the GROα-enriched microenvironment, ...
The rich factor is the ratio of the number of differentially expressed genes enriched in the indicated pathway to the number of all genes annotated in this pathway. D The bar plot shows GO enrichment analysis results in three major GO subclasses for downregulated genes using the GO database. ...
Nuclear deformability largely arises from lamins within the nuclear envelope and chromatin [194,195]. In single isolated nuclei, lamin A/C level and chromatin regulate nuclear strain stiffening at large (>3 μm) and small deformation (<3 μm), respectively. The ratio of euchromatin/heteroch...
The myCAF to iCAF ratio varied across samples, while the proportional distribution of both subpopulations in relation to Moffitt subtype distribution was not significantly different (Fig. 3D). In myCAFs, SDC131, a gene linked to CAF-mediated regulation of breast cancer cell migration, was upregu...
(Fig.5d–fand Supplementary Fig.10). Due to the nanoassembly-enhanced generation and activation of tumor-specific effector T cells, the apoptosis ratio of the 4T1 tumor cells in the 4T1/splenic immune cell co-culture system increased substantially from 2.8% in the control group to 80.4% in...