Results showed that patients' survival did not correlate with the quantity nor the quality of neoantigens. However, only when the cytotoxic activity of tumor infiltrating lymphocytes was low, a correlation between neoantigens and survival was observed, suggesting that in this setting a higher number...
Here, we report that predicted neoantigen load may be a prognostic factor in hypomutated endometrial cancers, both in CN-low/endometrioid and CN-high/serous-like tumors. Specifically, in the TCGA dataset, CN-low/endometrioid tumors with neoantigen load in the highest tertile were associated with ...
Workel HH, Lubbers JM, Arnold R, Prins TM, van der Vlies P et al. A transcriptionally distinct CXCL13(+)CD103(+)CD8(+) T-cell Population is Associated with B-cell recruitment and Neoantigen load in Human Cancer. Cancer Immunol Res, 75. Shaul ME, Zlotnik A, Tidhar E, Schwartz A, ...
Samstein, R.M., Lee, CH., Shoushtari, A.N.et al.Tumor mutational load predicts survival after immunotherapy across multiple cancer types.Nat Genet51, 202–206 (2019). https://doi.org/10.1038/s41588-018-0312-8 Download citation
Neoantigen load has also been correlated with response to immunotherapy [22]. However, no recurrent neoantigens have been found that predict response to date [23]. Increased mutation rate is a well-characterized feature of human cancer. Abnormal activity in several cellular pathways, including DNA ...
which target known tumor-associated antigens and neoantigens. After understanding the HLA layout of the patient, as well as the natural immunogenicity of the tumor, the vaccine can be adjusted by selecting a matching peptide for vaccination. This reduces the risk of severe adverse events simply ...
Part of the reason for the variability in TMB results may be that tTMB and bTMB are surrogate biomarkers in that they measure a phenotype that is indirectly related to neoantigen load, which itself is distal to the direct action of anti-PD-L1/PD-1 therapies. Moreover, tTMB and bTMB do ...
Tumor neoantigens: from basic research to clinical applications, 2019 For viral tumors, can use epitopes derived from ORF of viral genomes Clonality is important: However, some cancers with high level of neoantigen load are not as sensitive to immune checkpoint inhibitors as expected. It is ...
Neoantigen-driven B cell and CD4 T follicular helper cell collaboration promotes robust anti-tumor CD8 T cell responses Cell, 184 (2021), pp. 6101-6118.e13, 10.1016/j.cell.2021.11.007 View PDFView articleView in ScopusGoogle Scholar Degn et al., 2017 S.E. Degn, C.E. van der Poel, ...
Tumor neoantigens: from basic research to clinical applications, 2019 For viral tumors, can use epitopes derived from ORF of viral genomes Clonality is important:However, some cancers with high level of neoantigen load are not as sensitive to immune checkpoint inhibitors as expected. It is likely...