potential neoantigen prediction tools, and clinical applications of neoantigen-based immunotherapy strategies. Moreover, we also discuss the opportunities and limitations associated with the clinical application of immunotherapies based on neoantigens and propose some potential solutions. ...
'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations Rosenberg and colleagues review evidence suggesting that T cells that target tumor neoantigens arising from cancer mutations are the main mediators of many effective cancer immunotherapies in humans. ...
We also discuss the potential benefits and obstacles to the development of effective cancer immunotherapies targeting neoantigens.关键词: Cancer immunotherapy Tumor immunology Neoantigen Mutation DOI: 10.1016/j.smim.2015.11.002 被引量: 76 年份: 2016 ...
Cancer immunotherapy targeting neoantigens Neoantigens are antigens encoded by tumor-specific mutated genes. Studies in the past few years have suggested a key role for neoantigens in cancer immunot... YC Lu,PF Robbins - 《Seminars in Immunology》 被引量: 71发表: 2016年 Neoantigens Generated ...
Lu, Y. C., and Robbins, P. F. (2016). Cancer immunotherapy targeting neoantigens. Semin. Immunol. 28, 22-27. doi: 10.1016/j.smim.2015.11.002Lu YC, Robbins PF. Cancer immunotherapy targeting neoantigens. Semin Immunol 2016; 28:22-7; PMID:26653770; http://dx.doi.org/ 10.1016/j....
(2021). Neoantigen: A New Breakthrough in Tumor Immunotherapy.Frontiers in Immunology,12. https://www.frontiersin.org/articles/10.3389/fimmu.2021.672356Zhao, X., Pan, X., Wang, Y., & Zhang, Y. (2021). Targeting neoantigens for cancer immunotherapy.Biomarker Research,9(1), 61. https://...
Theoretically, tumor neoantigens are ideal cancer immunotherapy targets, because they are foreign proteins truly absent from normal human tissues. As a result, tumor-killing T cells with specificity for these neoantigens can escape negative selection in the thymus and are less likely to trigger ...
immunotherapy such as checkpoint inhibitors and CAR T cells, vaccines targeting neoantigens are designed to be individual-specific. This personal vaccine induces a focused T cell response to patient’s specific tumor neoantigens and avoids toxicities caused by damage to normal cells and tissues [119...
Targeting histone modifications in cancer immunotherapy EsterMunera-Maravilla, ...MartaDueñas, inHistone Modifications in Therapy, 2020 15.1Introduction Cancer immunotherapyis based on the activation or reactivation of the immune response against tumor cells and reverts the immune-tolerant state that gene...
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