Tumor-mutation burden TNB: tumor neoantigen burden PBMC: Peripheral blood mononuclear cells ACC: Adrenocortical Carcinoma BLCA: Bladder Urothelial Carcinoma BRCA: Breast invasive carcinoma CESC: Cervical squamous cell carcinoma and endocervical adenocarcinoma CHOL: Cholangio carcinoma COAD: Colon...
Exploring the relationship between intratumoral heterogeneity (ITH), tumor neoantigen burden (TNB), and human leukocyte antigen loss of heterozygosity (HLA LOH) can deepen our understanding of the immune evasion mechanisms.Methods:In this study, whole exome sequencing (WES) was employed to analyze ...
所以与肿瘤突变数量直接相关的肿瘤突变负荷(TMB)会是一个重要的标志物。而如果进一步对突变进行区分,考虑一个突变是不是能够产生足够合适的新抗原,则可以导出另一个近期开始获得关注的标志物,即肿瘤新抗原负荷(Tumor Neo-antigen Burden, TNB) 2. 为了跟肿瘤细胞中产生的新抗原更好地绑定,需要有足够丰富多样的MHC系...
one can define a metric "tumor neoantigen burden" (TNB) derived from neoantigen abundancy and/or quality that would relate to the the immune system activity in cancer suppression. It can be used, for example, to: predict clinical outcomes to immune checkpoint blockade ...
Methods: The ICIs treatment NSCLC cohort from the Memorial Sloan Kettering Cancer Center (MSKCC) was used for exploring the associations of mutations in the clock genes (CLOCK, BMAL1, CRY1, CRY2, PER1, PER2, and PER3) with TMB, tumor neoantigen burden (TNB), and ICIs efficacy. The ...
Cancer cells with high amount of neoantigens are more likely to be captured by immune cells and thus patients with high Tumor Mutation Burden(TMB) and high Tumor Neoantigen Burden(TNB) are estimated to be prone to ICIs treatment. HLA class Ⅰ is one of the main factors affecting the ...
A method and a system for calculating tumor neoantigen burden (TNB) are provided. The method includes: step S1: processing a normal sample and a tumor sample, sequencing a specific region and detecting somatic mutations in the sample; step S2: annotating and filtering the somatic mutations, and...
Whole exon sequencing (WES) was conducted to investigate the tumor mutational burden (TMB) and tumor neoantigen burden (TNB). Results: Compared to paired PTs, RTs exhibited higher PD-L1 expression, along with a slightly elevated density of intratumoral PD-L1+ cells (p = 0.082) and an ...
Among them, tumor cells-derived biomarkers include tumor mutational burden (TMB) biomarker, tumor neoantigen burden (TNB) biomarker, microsatellite instability (MSI) biomarker, PD-L1 expression biomarker, mutated gene biomarkers in pathways, and epigenetic biomarkers. TIME-derived...
Calculate the tumor neoantigen burden (TNB) metric by either taking the highest score among peptides, or somehow summarize scores of all potent peptides. Use potent peptides to design a vaccine for testing in vitro. Tools MHC binding prediction methods ...