(RT). Overall, PD-1/PD-L1 affects the process of T cell activation and infiltration by affecting the PI3K-AKT pathway, leading to upregulation of the expression of theimmune checkpointTIM-3, deletion ofPTEN, and other conditions. Based on the discovery of these mechanisms, a number of ...
Each Dunn test raw p-value was adjusted for multiple testing using the Benjamini-Hochberg (BH) procedure to control the false discovery rate (FDR), and a threshold FDR ≤0.05 was used to determine statistical significance. Permutation tests were performed by shuffling dataset class labels 1000 ...
Biology and therapeutic targeting of vascular endothelial growth factor A. Nat. Rev. Mol. Cell Biol. 24, 816–834 (2023). Article PubMed Google Scholar Simons, M., Gordon, E. & Claesson-Welsh, L. Mechanisms and regulation of endothelial VEGF receptor signalling. Nat. Rev. Mol. Cell ...
Discovery and characterization of a neutralizing pan-ELR+CXC chemokine monoclonal antibody. MAbs. 2020;12(1):1831880. Google Scholar Download references Acknowledgments We would like to thank Dr. Simon Chu (Hudson Institute of Medical Research, Melbourne, Australia) for providing the CAOV3 cell ...
Ji HP. GITR and TIGIT immunotherapy tumor slice culture scRNA-seq: Ji Research Group, Stanford University; 2023 [Available from: https://dna-discovery.stanford.edu/research/datasets/]. Accessed 21 Nov 2023. Download references Acknowledgements We are grateful to all patients who participated in the...
2023, Drug Discovery Today Citation Excerpt : Similarly, Yang et al. constructed a complex micelle system (SPP-ARV-825) composed of substance P (SP)-peptide-modified poly(ethylene glycol)-poly(d,l-lacticacid) (SP-PEG-PDLLA) and methoxy poly(ethylene glycol)-poly(d,l-lactic acid) (mPEG-...
In 2023, the CTC detection and enrichment methods segment accounted for the largest revenue share of 66.21%. The availability of different methods for the enrichment of circulating tumor cells in cancer detection is expected to significantly impact segment growth over the forecast period. Moreover, ...
In addition, the discovery of intracranial lymphatic vessels has led to an increased recognition of the importance of immune cells in brain tumors, challenging previous assumptions about brain tolerance and immune privilege4. Glioma is characterized by a highly suppressive and unique “cold” immune ...
Review Article Open access Published: 01 December 2023 Tumor-suppressive functions of protein lysine methyltransferases Nur Aziz, Yo Han Hong, Han Gyung Kim, Ji Hye Kim & Jae Youl Cho Experimental & Molecular Medicine volume 55, pages 2475–2497 (2023)Cite this article 2619 Accesses 4 ...
2023, Chem Citation Excerpt : In addition, the identification of lead compounds greatly benefits from FBDD strategies. Therefore, to optimize lead compounds and highlight the potential application of this Rh-catalyzed two-component dual C–H activation macrocyclization in the construction of drug-like...