ISSN 21598274, 21598290 Coverage 2011-2023 Information Homepage How to publish in this journal pubs@aacr.org Scope Cancer Discovery publishes high-impact, peer-reviewed articles describing major advances in research and clinical trials. As the premier cancer information resource, the Journal also present...
After our de novo signature discovery analysis, functions from the R package deconstructSigs (v.1.9.0)58with the normalization parameter exome2genome were applied to deconvolve SBS signatures from the TRACERx 421 WES data using COSMIC (v.3.2) signatures57as reference. Only signatures that were ...
Each Dunn test raw p-value was adjusted for multiple testing using the Benjamini-Hochberg (BH) procedure to control the false discovery rate (FDR), and a threshold FDR ≤0.05 was used to determine statistical significance. Permutation tests were performed by shuffling dataset class labels 1000 ...
After the discovery of the dysregulation of miRNA expression itself being associated with human disease progress and therapy response, the introduction of a disease suppressor miRNA mimic to restore its functionality is one therapeutic approach under careful consideration [144]. To date, dozens of miRNA...
Expertise how most cancers develops and progresses, together with how gene mutations pressure the increase and spread of most cancers cells, and how tumours interact with their surrounding environment, is vital for the discovery of recent centered cancer remedies. Track 2: Cancers & Stem Cell ...
Previous studies have reported the discovery of TLSs in bladder cancer patient tissues and confirmed that well-developed TLSs are more common in aggressive high-grade MIBC tumors than in low-grade NMIBC [11]. The presence of TLSs as well as their components, such as follicular B cells, ...
Applied statistical tools include Cox proportional hazards regression and the computation of the False Discovery Rate. The tool's primary purpose is the discovery and validation of survival biomarkers OncoLnc Here you can link TCGA survival data to mRNA, miRNA, or lncRNA expression levels. To get ...
Diagnostics2023,13(21), 3314;https://doi.org/10.3390/diagnostics13213314 (This article belongs to the SectionMachine Learning and Artificial Intelligence in Diagnostics) Downloadkeyboard_arrow_down Browse Figures Versions Notes Abstract Aim: Method: This research presents a model combining machine learning...
2023 Sensational mechanism of occurrence of half of all cancer cases in the world revealed On November 28, 2023, Australian specialists from the Walter and Eliza Hall Institute for Medical Research (WEHI) announced an important discovery that sheds light on the mechanism of occurrence of half of ...