Cancer Discovery publishes high-impact, peer-reviewed articles describing major advances in research and clinical trials. As the premier cancer information resource, the Journal also presents Review Articles, Perspectives and Commentaries, News stories, and Research Watch summaries of important journal artic...
Track 2: Anti-Cancer Drug Discovery and Development Evolution of drugs to selectively interfere with and slow down tumour growth has now entered a new and exciting era of the target orientated approach. Drugs are now being evolved against specific proteins included in cancer cell growth that have...
Each Dunn test raw p-value was adjusted for multiple testing using the Benjamini-Hochberg (BH) procedure to control the false discovery rate (FDR), and a threshold FDR ≤0.05 was used to determine statistical significance. Permutation tests were performed by shuffling dataset class labels 1000 ...
After our de novo signature discovery analysis, functions from the R package deconstructSigs (v.1.9.0)58with the normalization parameter exome2genome were applied to deconvolve SBS signatures from the TRACERx 421 WES data using COSMIC (v.3.2) signatures57as reference. Only signatures that were ...
Leaders at City of Hope forecast that in 2024 more people will benefit from cancer breakthroughs, including research that unlocks the biology behind cancer disparities, wider access to CAR T cell therapy and rapid whole genome sequencing.
Previous studies have reported the discovery of TLSs in bladder cancer patient tissues and confirmed that well-developed TLSs are more common in aggressive high-grade MIBC tumors than in low-grade NMIBC [11]. The presence of TLSs as well as their components, such as follicular B cells, ...
For both tests, we corrected for multiple testing using the false discovery rate (FDR) method [66]. Co-occurrence We tested for co-occurrence of functional gene mutations with PMS2 promoter mutations using logistic regression. We fit a model of the type: status of PMS2 promoter mutations in...
The abbreviations used are: CNA, copy number alteration; QT, quantitative trait; HGSOC, high-grade serous ovarian carcinoma; TCGA, The Cancer Genome Atlas; CPTAC, Clinical Proteomic Tumor Analysis Consortium; FDR, false discovery rate; eQTC, expression quantitative trait CNA; pQTC, global protein...
B. et al. Discovery and characterization of gut microbiota decarboxylases that can produce the neurotransmitter tryptamine. Cell Host Microbe 16, 495–503 (2014). Article CAS PubMed PubMed Central Google Scholar Bauknecht, P. & Jekely, G. Ancient coexistence of norepinephrine, tyramine, and ...
ReviewsOpen Access18 Dec 2024Cell Death Discovery Volume: 10, P: 490 Cancer-type somatic mutations in saccular cerebral aneurysms Behnam Rezai Jahromi Miko Valori Mika Niemelä ResearchOpen Access12 Dec 2024European Journal of Human Genetics ...