Recent research has suggested that cancer cells can also make nanoparticles that also deliver functional molecules in promoting cancer metastasis, which is the leading cause of various cancer mortalities.This nanoparticle is called tumor-derived vesicles, or better-known as tumor-derived exosomes(TEXs)...
Tumor-derived exosomal components: the multifaceted roles and mechanisms in breast cancer metastasis. Cell Death Dis. 2021;12(6):547. CAS Google Scholar Wu M, Wang G, Hu W, Yao Y, Yu XF. Emerging roles and therapeutic value of exosomes in cancer metastasis. Mol Cancer. 2019;18(1):53...
511 in TC to 12,736 in KIRC. Then, for each DEG in each cancer type, we divided the tumor samples into 2 categories based on the median normalized expression of this DEG in the corresponding cancer type (i.e., samples with expression values of the DEG higher than the median were defin...
(Detroit, MI), which established and authenticated the cells. The CAFs were immortalized using a lentiviral transduction system of hTERT purchased from Applied Biological Materials (Richmond, BC). PDAC organoids derived from KPC mice were prepared as described previously51. All the CAFs, organoids...
One of the key processes involved in cancer development is that cancer cells acquire immune escape by inducing and recruiting immunosuppressive cells, such as Treg cells, bone marrow-derived suppressor cells, and tumor-associated macrophages, as well as increasing the expression of various immunosuppress...
Recent research has dramatically advanced our understanding of the genetic basis of multiple myeloma (MM). MM displays enormous inter- and intratumoral heterogeneity, and underlies a clonal evolutionary process driven and shaped by diverse factors such as clonal competition, tumor microenvironment, host ...
Mouse 4T1 breast cancer cell-derived exosomes induce proinflammatory cytokine production in macrophages via miR-183. J Immunol. 2020;205(10):2916–2925. doi: 10.4049/jimmunol.1901104. (Open in a new window)PubMed (Open in a new window)Web of Science ®(Open in a new window)Google ...
Bone marrow stromal cell-derived exosomes as communicators in drug resistance in multiple myeloma cells. Blood. 2014;124:555–66. CAS PubMed Google Scholar Yamamoto T, Kosaka N, Hattori Y, Ochiya T. A challenge to aging society by microRNA in extracellular vesicles: microRNA in extracellular...