However, some patients fail to respond to immunotherapy, and emerging evidence indicates that tumor-derived exosomes (TEX) play a major role in reprogramming the host immune cells by inducing their dysfunction. Focusing on effector T cells, this review illustrates mechanisms of suppression that TEX ...
Cancer metastasis is a complex, multistage process, which eventually causes tumor cells to colonize and grow at the metastatic site16. Exosomes derived from tumors and stromal cells have been involved in all stages of cancer metastasis. In addition to the different types of substances loaded in e...
Tumor cell-derived exosomes (TEX) have been widely used to induce antitumor immune responses in animal models and clinical trials. However, the efficiency of the antitumor immunity that is induced by \\\{TEX\\\} is still relatively weak. In this study, we compared the antitumor immunities bet...
In this article, we present a systematic literature review and analysis of the role of TAMs-derived exosomes in tumorigenesis. We summarize how TAMs-derived exosomes regulate interactions between tumor cells and other cells in the TME, as well as the relationship between TAMs-derived exosomes and ...
Bone marrow-derived cellsExosomesPD-L1Tumors escape immune attack by upregulating the surface expression of PD-L1, which interacts with PD-1 on T cells to activate immune inhibitory signaling. Anti-PD-1 treatments can effectively block this inhibitory signaling and activate antitumor immune responses....
基于树突状细胞(dendritic cell,DC)的肿瘤免疫疗法主要依靠肿瘤抗原或肿瘤裂解物激活DC,并作为抗原呈递细胞促进靶向肿瘤,引发适应性免疫反应。最新研究发现肿瘤细胞来源的外泌体(tumor cell-derived exosomes,TEXs)上修饰HMGN1功能域可增强DC的免疫原性,激活T细胞肿瘤杀伤能力,抑制小鼠肿瘤,相关研究结果发表在Nature Communi...
Malignancies can compromise innate immunity, but the mechanisms of this are largely unknown. Here we found that, via tumor-derived exosomes (TEXs), cancers were able to transfer activated epidermal growth factor receptor (EGFR) to host macrophages and thereby suppress innate antiviral immunity. Scree...
In the immune microenvironment of melanoma, tumor-derived EVs influence tumor progression by regulating innate and adaptive immune responses. Tumor-derived EV-based therapy is a cutting-edge and promising strategy for inhibiting melanoma progression and enhancing antitumor immunity. This review aimed to ...
Moreover, the proportion of regulatory T cells is decreased, while the proportion of myeloid-derived suppressor cells does not alter after resveratrol treatment. More importantly, massive amount of activated CD8 + T cells accumulates in tumor microenvironment in the resveratrol-treated group and shows...
Malignancies can compromise innate immunity, but the mechanisms of this are largely unknown. Here we found that, via tumor-derived exosomes (TEXs), cancers were able to transfer activated epidermal growth factor receptor (EGFR) to host macrophages and th