Histology showed spindled and epithelioid tumor cells immunopositive for HMB-45, desmin, TFE3, SMA, caldesmon, Melan-A and calretinin. Cytokeratin, S-100, inhibin, myogenin, and OCT3/4 immunostains were negative. In 2013 the patient re-presented with chest pain. Imaging confirmed a ...
Primary tumors may create the premetastatic niche in secondary organs for subsequent metastasis. Humoral immunity contributes to the progression of certain cancers, but the roles of B cells and their derived antibodies in premetastatic niche formation ar
respectively. Cells within tumor tissues experience solid mechanical stress from the structural components and interstitial fluid pressure (IFP). The upper-left quarter of (A) and (B) shows the solid stress distribution. The left-bottom quarter shows the IFP distribution. Tumor tissue has higher ...
Granular cell tumor is a unique tumor composed of sheets of cells with abundant eosinophilic, granular cytoplasm. The cytoplasm, which is periodic acid–Schiff positive, ultrastructurally contains a large numbers of secondary lysosomes. Neoplastic cells display a characteristic immunoreactivity for S100 pr...
For example, peritumoral T cell and B cell infiltration in colorectal cancer patients is correlated with positive prognosis, whereas the depletion of lymphocytes in the tumor core is an indicator of poor prognosis [25]. Further, stromal infiltration of T cells is linked to good prognosis for ...
SMA + p-STAT3 + cells, which might subsequently be a potential target for tumor immunotherapies [99]. Moreover, in colorectal cancer, CAF-A cells (one of the CAF subtypes) were reported to be capable of converting into CAF-B cells (another CAF subtype) during the transformation ...
Blood–Brain Barrier (BBB)The BBB is a unique component of the brain that allows for the maintenance of homeostasis in the CNS by forming a tightly regulated neurovascular unit that includes endothelial cells, pericytes, and astrocytes [3]. In the GBM TME, the BBB is disrupted and displays ...
Steroid hormones affect binding of the sigma ligand 11C-SA4503 in tumour cells and tumour-bearing rats Purpose Sigma receptors are implicated in memory and cognitive functions, drug addiction, depression and schizophrenia. In addition, sigma receptors... AA Rybczynska,PH Elsinga,JW Sijbesma,......
and tumor-infiltrating myeloid cells prompt malignancy by activating pro-tumorigenic signaling pathways, such as the MIF/CD74 and IL34/CSF1R axes in myeloid cells, as well as enhancing the aggressive phenotypes of MFAP5 + fibroblasts through EGF and VISFATIN signals in a positive loop. There...
4b). Additionally, western blotting showed that the expression of αSMA was significantly upregulated in JS1 cells (P < 0.05) (Fig. 4c). Immunofluorescence analysis also showed a significant increase in the number of αSMA-positive cells among JS1 cells (P < 0.01) (Fig. 4d). In...