Histologically, the tumor was multinodular and rich in blood vessels with thin wall; the interstitium had abundant myxomatous stroma; the tumor cells were spindle-shaped, star-shaped, or oval. Immunohistochemica
Immunohistochemically, the tumor cells were positive for HMB45, SMA, desmin and caldesmon and were weakly positive for Melan-A (Fig. 3f, g). The nuclei of tumor cells were partially positive for TFE3 (Fig. 3h). The vascular network was clearly delineated using CD34 and CD31 staining. The...
Thus, there is a strong need to find new targets and develop medical therapies to effectively cure cancer that is diagnosed in late stages. Recent studies have focused on stromal cells within the cancer niche [2], [3]. A tumor not only comprises cancer cell clones but also consists of a...
A 94‐year‐old male presented with a right‐sided ulcerated scalp lesion, which, on biopsy, showed a diffusely infiltrative epithelioid malignancy with considerable pleomorphism and a notable perivascular growth pattern. The tumor cells were positive for smooth muscle actin (SMA) and h‐caldesmon,...
IHC staining showed that tumor cells were positive for alpha-smooth muscle actin (伪-SMA) and h-caldesmon in all seven cases and negative for cluster of differentiation 34 (CD34) in 72.14%. IHC stainings for p63, S100, cytokeratin (CK) AE1鈭旳E3 were negative in all cases...
The tumor cells had well-defined cell membranes, centrally placed, round nuclei and amphophilic cytoplasm. Immunohistochemical staining showed the positive expression of smooth muscle actin (SMA), caldesmon and vimentin; meanwhile detecting the negative expression of desmin, pan-cytokeratin, CD34, CD117...
Immunostains showed the tumor cells to be focally positive for SMA (6/6), focally and weakly positive for desmin (3/6) and caldesmon (2/3), negative for CD117 (0/7), CD34 (0/7), DOG1 (0/4), and S100 (0/5). No mutations were identified on NextGeneration Sequencing test, ...
Immunohistochemical staining is another tool used in diagnosing STUMP: progesterone receptor (PR) is often positive in STUMPs, reflecting hormonal influence; Smooth Muscle Actin (SMA) and Caldesmon are typically positive, indicating smooth muscle differentiation; Desmin is positive in most cases, supportin...
Using two BC single-cell RNA sequencing datasets, iCAFs were found to associated with high infiltration of CD8 T-cells, regulatory T-cells, and M2 and exhausted T-cells [71]. In another analysis of the TCGA database, pathway analysis revealed CAF-associated calcium-binding protein caldesmon (...
Immunohistochemically, the tumor cells were positive for desmin, MYOD1 and SMA, focally positive for myogenin, while negative for h-caldesmon, SOX10 and S100P. A diagnosis of inflammatory leiomyosarcoma/HRRT was offered. Subsequently, the tumor was tested for MYOD1 (L122...