TT-00920是一种高效，高选择性的磷酸二酯酶9（PDE9）小分子抑制剂，用于治疗慢性心力衰竭。PDE9蛋白表达量和活性在心衰患者中显著上升，干扰调节心脏功能的天然“制动”系统。TT-00920靶向抑制PDE9，激活心肌内源保护作用机制。临床前心衰动物模型研究显示，TT-00920可显著改善心脏功能，并逆转心肌重构。药捷安康TT-0...
TT-00920 is an investigational, highly potent and selective PDE9 inhibitor for the treatment of chronic heart failure. PDE9 protein interferes with a body's natural "braking" system needed to neutralize stress on the heart and has shown...
公司计划于2020年初在美国启动一期临床试验,评估TT-00920在健康受试者体内的安全性、耐受性和药代动力学特征。 TT-00920是一个高活性、高选择性的磷酸二酯酶9A(PDE9A)抑制剂,用于治疗慢性心衰。PDE9A靶点和心衰存在高度疾病关联性,抑制PDE9A可提高心肌cGMP水平,激活失调的心脏保护机制,保护心肌细胞免受损伤。临床...
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TT-00920是一种高效,高选择性的磷酸二酯酶9(PDE9)抑制剂,用于治疗慢性心力衰竭。 药捷安康生物副总裁盛泽娟博士表示:“心衰在中国存在巨大未被满足的临床需求。TT-00920通过全新药物作用机制,激活心肌内源保护信号通路,有潜力成为治疗慢性心衰的突破性药物。我们期待TT-00920的临床研究为中国心衰患者提供新的革命性治...
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