One strategy for the direct detection of the chronic inflammatory activity associated with this disease is to use positron emission tomography (PET) radioligands targeting cellular markers of inflammation. The 18-kDa Translocator Protein (TSPO) is a mitochondrial transmembrane protein and widely used PET...
(PFDA) inhibits the Leydig cell steroidogenesis by affecting PBR mRNA stability, thus inhibiting PBR expression, cholesterol transport into the mitochondria and subsequent steroid formation. A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found ...
TSPO abolishes mitochondrial relocation of SQSTM1/p62 (sequestosome 1), and consequently that of the autophagic marker LC3 (microtubule-associated protein 1 light chain 3), thus leading to an accumulation of dysfunctional mitochondria, altering the appearance of the network. Independent of cholesterol ...
A cytoplasmic protein, PRAX-1 ( peripheral benzodiazepine receptor-associated protein 1), is found to specifically interact with PBR. 仅用于科研。不用于诊断过程。未经明确授权不得转售。相关产品 免疫组织化学 Secondary Antibodies 同型对照 IHC封片剂 IHC细胞计数染料 IHC封闭剂 ...
A DREADD-based chemogenetic approach was used to examine whether TSPO mRNA and protein levels change in response to selective neuronal activation. The following adeno-associated viruses (AAVs) were used: AAV8-hSyn1-hM3D(Gq)-mCherry (hM3DGqV) and AAV8-hSyn1-EGFP (ConV). They were purchase...
One strategy for the direct detection of the chronic inflammatory activity associated with this disease is to use positron emission tomography (PET) radioligands targeting cellular markers of inflammation. The 18-kDa Translocator Protein (TSPO) is a mitochondrial transmembrane protein and widely used PET...
Alzheimer’s disease (AD) is characterized by the accumulation of β-amyloid peptide (Aβ). It affects cognition and leads to memory impairment. The mitochondrial translocator protein (TSPO) plays an essential role in maintaining mitochondrial homeostasi
Based on this evidence, we set out to probe whether neurotoxin-induced mitochondrial damage is associated with the upregulation of TSPO and deregulation of mitophagy. We did so aware that: (i) TSPO expression is driven by activation of the extracellular signal-regulated protein kinases (ERKs) [...
The 18 kDa translocator protein (TSPO), formerly known as the peripheral-type benzodiazepine receptor, has been reported to be closely associated with the mitochondrial permeability transition pore (MPTP). TSPO is believed to exert pro-a... Sivan Zeno, Menashe Zaaroor, Svetlana Leschiner, Leo ...
An aberrant pro-inflammatory microglia response has been associated with most neurodegenerative disorders. Identifying microglia druggable checkpoints to r