Neurodegenerative Diseases: Tryptophan Metabolism. Figure1 Simplified diagram of the kynurenine pathway. Characteristics Quantitative Description In physiological conditions, concentrations of most of the kynureni ...doi:10.1007/978-3-540-29678-2_3821Gilles J. Guillemin...
Abnormal Expression of Tryptophan Metabolism in Cancers and Its Correlation with Clinicopathological Features and Prognosis Differentially abnormal expression of tryptophan metabolism and related molecules involved in cancer progression and patient outcomes. Critical enzymes in the tryptophan metabolism pathway, suc...
particularly IDO and TDO, has yielded promising advancements in cancer therapy [238472392402) [82,241]. Moreover, increasing evidence supports the therapeutic potential of targeting other key enzymes in the tryptophan metabolism pathway, such as KMO and TPH,...
Its metabolism is a multi-pathway process. Indole and its derivatives are Trp metabolites unique to the human gut microbiota. Changes in Trp metabolism have also been detected in colorectal cancer (CRC). Here, combined with the existing CRC biomarkers, we ascribed it to the altered bacteria ...
Products of tryptophan metabolism have been implicated in the neuropathogenesis of HIV.48 Tryptophan (Trp) is an essential amino acid involved in the metabolic pathways for serotonin and subsequently melatonin and for nicotinamide adenine dinucleotide (NAD+) (Fig. 28.7). In the latter pathway, also...
The metabolism of tryptophan and tryptophan metabolites was investigated during the follicular, luteal and premenstrual phases of the menstrual cycle in 33 healthy women across one cycle. The metabolites of all three pathways of tryptophan ie the serotonergic pathway, the pyrollase pathway and the ...
We define the IDH-dependent tumor education of infiltrating macrophages to be causally related to a complex re-orchestration of tryptophan metabolism, resulting in activation of the aryl hydrocarbon receptor. We further show that the altered metabolism of IDH-mutant gliomas maintains this axis in ...
l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the KP,...
In this chapter, shifting tryptophan metabolism from serotonin synthesis to the generation of neuroactive metabolites, such as quinolinic acid and kynurenic acid, by the kynurenine pathway is now considered to play an important a role in the pathogenesis of inflammation-dependent depression. The ...
metabolism and MetS development in older adults. Notably, the KYN/TRP, 5-HT/TRP, and IPA/TRP ratios represent the conversion ratios between metabolites in a metabolic pathway and the potential activity of the participating enzymes. Among these ratios, the 5-HT/TRP ratio is significantly ...