Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the KP, particularly the main rate-limiting enzymes indoleamine-2,3-dioxygenase 1 (IDO1), IDO2 and tryptophan-2,3-dioxygenase (TDO) as well as kynurenine ...
In conclusion, we provide evidence of a glioma genotype-dependent intratumoral network of resident and recruited myeloid cells and identify tryptophan metabolism as a target for immunotherapy of IDH-mutant tumors.Similar content being viewed by others Immune landscape of oncohistone-mutant gliomas reveals...
Tryptophan Metabolism acts as a New Anti-ferroptotic Pathway to Mediate Tumor Growth. Adv Sci (Weinheim Baden-Wurttemberg Germany). 2023;10(6):e2204006. Google Scholar Janiszewska M, Primi MC, Izard T. Cell adhesion in cancer: beyond the migration of single cells. J Biol Chem. 2020;...
Tryptophan Metabolism acts as a New Anti-ferroptotic Pathway to Mediate Tumor Growth. Adv Sci (Weinheim Baden-Wurttemberg Germany). 2023;10(6):e2204006. Google Scholar Janiszewska M, Primi MC, Izard T. Cell adhesion in cancer: beyond the migration of single cells. J Biol Chem. 2020;...
This chapter discusses tryptophan metabolism in mental illness. 5-hydroxytryptamine (5-HT) was first recognized as a peripheral vasoconstrictor and a substance that causes various smooth muscles to contract. Its presence in considerable amount in blood platelets, skin, and intestine indicates that its...
This enzyme is so named because it also acts on kynurenine. In this case the dead-end product anthranilate is formed. While the conversion of kynurenine to 3-HK is a major step in the metabolism of tryptophan, kynurenine can also be transaminated to kynurenate by a number of amino...
This is a 3.9-fold increase to the natural producer with the supplementing of the precursor L-Trp [24]. Meanwhile, our engineering process also contributed to discovering many new insights into the regulation of AAAs metabolism, as well as the identification of yeast mutants that accumulate ...
(Fig.2B, C), as the first and rate limiting step inLactobacillus-specific tryptophan metabolism, we expected to observe a tryptophan-dependent increase in indole-3-pyruvate (Fig.3B). Indole-3-pyruvate was not detected in any of our samples, perhaps because this metabolite is quickly shunted ...
Therefore, in the present study, primary rat hepatocytes were used as a model for evaluating the enantioselective metabolism and toxicity of hexaconazole. Toxicology approaches might be incorporated into alternative test systems to further increase the predictivity of these tests and to provide mechanistic...
The activation of TLRs by microbial components, such as LPS and lipoteichoic acids, has been identified as a key factor in initiating the tryptophan metabolism through the kynurenine pathway, and the stimulation of TLR-2, TLR-3, TLR-4, TLR-7/8, and TLR-9 has been found to induce the ...