Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond Michael Platten, Ellen A. A. Nollen, Ute F. Röhrig, Francesca Fallarino & Christiane A. Opitz Nature Reviews Drug
A. Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat. Rev. Drug Discov. 18, 379–401 (2019). Pfefferkorn, E. R., Rebhun, S. & Eckel, M. Characterization of an indoleamine 2,3-dioxygenase induced by gamma-interferon in cultured human ...
Opitz CA Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discov. 2019;18:379–401. Article CAS PubMed Google Scholar Comai S, Bertazzo A, Brughera M, Crotti S. Tryptophan in health and disease. Adv Clin Chem. 2020;95:165–218....
Together, these data implicate tryptophan metabolism as a potent metabolic regulator of ageing and age-related diseases, offering new avenues for disease intervention. In addition, owing to the high conservation of tryptophan metabolism throughout evolution, small model organisms provide powerful tools to...
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discovery. 2019;18(5):379–401. Article PubMed CAS Google Scholar Cheong JE, Sun L. Targeting the IDO1/TDO2-KYN-AhR pathway for Cancer Immunotherapy - challenges and opportunities. ...
decreases the rate of protein synthesis in cancer cells, and down-regulate PD-L1 expression in H1975 cells.In Conclusion, these experimental results suggest a potential of the inhibition of TDO2/IDO1 activities in the tryptophan metabolism as a new therapeutic target for non-small cell lung ...
The latest evidence revealing those mechanisms by which the gut microbiota modulates tryptophan metabolism, with subsequent effects on brain function, is reviewed. Finally, the potential modulation of intestinal tryptophan metabolism as a therapeutic option for brain and GI functional disorders is also ...
Le Floc'h N, Otten W, Merlot E (2011) Tryptophan metabolism, from nutrition to potential therapeutic applications. Amino Acids 41:1195-1205LE FLOC'H N; OTTEN W; MERLOT E.Tryptophan metabolism, from nutrition to potential therapeutic ap- plications.Amino Acids.2011.205-1195...
Metabolic reprogramming stands as a pivotal hallmark of cancer, where tumor cells adeptly alter their metabolic pathways to meet energy and biosynthetic demands, evading immune surveillance and therapeutic interventions1,2. While amino acid metabolism plays an important role in supporting tumor growth, re...
Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond. Nat Rev Drug Discovery. 2019;18(5):379–401. Article CAS PubMed Google Scholar Cervenka I, Agudelo LZ, Ruas JL. Kynurenines: Tryptophan’s metabolites in exercise, inflammation, and mental health. ...