Neurodegenerative Diseases: Tryptophan Metabolism. Figure1 Simplified diagram of the kynurenine pathway. Characteristics Quantitative Description In physiological conditions, concentrations of most of the kynureni ...doi:10.1007/978-3-540-29678-2_3821Gilles J. Guillemin...
We define the IDH-dependent tumor education of infiltrating macrophages to be causally related to a complex re-orchestration of tryptophan metabolism, resulting in activation of the aryl hydrocarbon receptor. We further show that the altered metabolism of IDH-mutant gliomas maintains this axis in ...
l-Tryptophan (Trp) metabolism through the kynurenine pathway (KP) is involved in the regulation of immunity, neuronal function and intestinal homeostasis. Imbalances in Trp metabolism in disorders ranging from cancer to neurodegenerative disease have stimulated interest in therapeutically targeting the KP,...
Overview of tryptophan metabolism. Metabolism of tryptophan results in the neurotransmitters serotonin and melatonin and, via the kynurenine pathway (KP), to nicotinamide adenine dinucleotide. Indoleamine 2,3-dioxygenase (IDO) catalyzes the first step in the KP and is upregulated in the setting of ...
Silver RM, McKinley K, Smith EA, Quearry B, Harati Y, Sternberg EM, et al. Tryptophan metabolism via the kynurenine pathway in patients with the eosinophilia-myalgia syndrome. Arthritis and Rheumatism 1992;35: 1097-105.Silver, R. M., K. McKinley, E. A. Smith, B. Quearry, Y. ...
R.: Differences in tryptophan metabolism between breast cancer patients with and without cancer at other sites. Cancer 26:767-770, 1970.De George, F. V., and Brown, R. R. Differences in Tryptophan Metabolism between Breast Cancer Patients with and without Cancer at Other Sites. Cancer, 26:...
Interferon-γ-induced tryptophan metabolism of human macrophages was compared to ten human neoplastic cell lines of various tissue origin and to normal der... G Werner-Felmayer,ER Werner,D Fuchs,... - 《Biochimica Et Biophysica Acta》 被引量: 603发表: 1989年 DNA microarray analysis of gene ...
Tryptophan metabolism, from nutrition to potential therapeutic applications Tryptophan is an indispensable amino acid that should to be supplied by dietary protein. Apart from its incorporation into body proteins, tryptophan is the... NL Floc'H,W Otten,E Merlot - 《Amino Acids》 被引量: 184发表...
Fig. 1: Gene targets and promoters for combinatorial engineering of tryptophan metabolism in S. cerevisiae. a Gene–gene interaction network built with Cytoscape, showing that pentose phosphate pathway and glycolysis are both in the core of metabolism in close proximity to many genes. Nodes are all...
Indoleamine 2,3-dioxygenase 1 (IDO1), the enzyme that catabolizes tryptophan (Trp) metabolism to promote regulatory T cells (Tregs) and suppress CD8+ T cells, is regulated by several intrinsic signaling pathways. Here, we found that tobacco smoke, a majo