The genes involved in tryptophan metabolism were obtained from the Molecular Signatures Database (MSigDB) (http://www.broadinstitute.org/gsea/msigdb/) 'KEGG_TRYPTOPHAN_METABOLISM'. Forty TMR genes were included, namely, AADAT, AANAT, ACAT1, ACAT2, ACMSD, AFMID, ALDH1B1, ALDH2, ALDH3A2, AL...
KEGG pathway enrichment analysis revealed tryptophan metabolism enriched most significantly. Among the tryptophan derivatives, L-tryptophan (L-Trp) and serotonin were relatively accumulated in DGs compared with HCs, while 5-hydroxyindoleacetic acid (5-HIAA) and indole-3-acetamide were depleted. ...
core, accessory, and unique genomic KEGG orthology identifiers were extracted for KEGG enrichment analysis using clusterProfiler [91]. TheL. reuteriaccessory genome was found to be enriched in amino acid metabolism and biosynthesis (Fig.1I and Tables S4-S6). Differentially abundant...
Additionally, for microbial metabolites, we used a targeted tryptophan assay rather than a broad metabolic profiling assay, which may miss the impacts of other metabolites on the lower airway immune microenvironment due to the complexity of lower airway flora metabolism. Finally, specific mechanistic ...
Nicotinamide and tryptophan metabolism play important roles in regulating tumor synthesis metabolism and signal transduction functions. However, their comprehensive impact on the prognosis and the tumor immune microenvironment of glioma is still unclear.
Akkermansia muciniphila inhibits tryptophan metabolism via the AhR/β-catenin signaling pathway to counter the progression of colorectal cancer. Int J Biol Sci 2023; 19(14):4393-4410. doi:10.7150/ijbs.85712. https://www.ijbs.com/v19p4393.htm Copy Other styles Download File import instruction ...
Nicotinamide and tryptophan metabolism play important roles in regulating tumor synthesis metabolism and signal transduction functions. However, their comprehensive impact on the prognosis and the tumor immune microenvironment of glioma is still unclear.
A third hypothesis is that dysbiosis leads to aberrant metabolism of dietary residues (e.g., choline) and/or endogenous metabolites (e.g., bile acids), which imapirs the export of lipids or elevates lipogenesis in the liver. A common denominator of these hypotheses is that progression toward...
e, Tryptophan metabolism through the host pathways (serotonin and kynurenine pathways) and microbial pathway (indole pathway). IDO1: Indoleamine 2,3-Dioxygenase 1; TPH1: Tryptophan hydroxylase 1; TMO: Tryptophan 2-Monooxygenase; TrD: Tryptophan Decarboxylase; IAM: Indole-3-Acetamide; IAA: Indole...
the ions like m/z 132.0 and m/z 79.9 were found. We speculated that m/z 79.9 was SO3. Fifth, to define its structure, some databases like Human Metabolome Database (http://www.hmdb.ca), KEGG (http://www.kegg.com) METLIN (https://metlin.scripps.edu), MassBank (https://massbank...